Gastric cancer is one of the most severe cancers, while the relationship between () and gastric cancer are still in dispute, and little work has been done to explore the microbial diversity between positive patients and negative patients. In the present work, a total of 43 gastric cancer patients and 10 healthy 53 participants were enrolled to compare the microbial differences in community structure in gastrointestinal tract between positive patients and negative patients with gastric cancer. Our results indicated that the abundance and diversity of gastrointestinal microbiota was slight lower in gastric cancer patients than that in healthy participants especially in intestine, while the abundance of some potential pathogens, e.g. , , and were higher in positive patients than negative patients. Therefore, our work suggests the various microbial diversity between positive patients and negative patients with gastric cancer, which contribute to deepen the understanding of the role of in gastric carcinogenesis and progression.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8990434PMC
http://dx.doi.org/10.7150/jca.69873DOI Listing

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