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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8987493 | PMC |
| http://dx.doi.org/10.3389/fcell.2022.887051 | DOI Listing |
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Institute for Biomedicine and Molecular Genetics, Unit of Excellence, University of Valladolid and Spanish National Research Council (CSIC), Valladolid, Spain.
Generation and characterization of OX40-ligand fusion protein that agonizes OX40 on T-Lymphocytes.
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OX40, a member of the tumor necrosis factor (TNF) receptor superfamily, is expressed on the surface of activated T cells. Upon interaction with its cognate ligand, OX40L, OX40 transmits costimulatory signals to antigen-primed T cells, promoting their activation, differentiation, and survivalprocesses essential for the establishment of adaptive immunity. Although the OX40-OX40L interaction has been extensively studied in the context of disease treatment, developing a substitute for the naturally expressed membrane-bound OX40L, particularly a multimerized OX40L trimers, that effectively regulates OX40-driven T cell responses remains a significant challenge.
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