AI Article Synopsis
- Patients with cirrhosis often suffer from sarcopenia, which can increase mortality rates, and this study investigates the impact of subclinical zinc deficiency on this condition.
- The research involved 151 cirrhosis patients, categorizing them into two groups: those with normal zinc levels and those with subclinical zinc deficiency, revealing a higher prevalence of sarcopenia in the latter.
- Results indicated a significant correlation between low zinc levels and increased sarcopenia risk, suggesting that maintaining adequate zinc levels could be important for improving patient outcomes.
Article Abstract
Background/aim: Sarcopenia increases the mortality in patients with cirrhosis. Approximately 60% of zinc is accumulated in skeletal muscle. We aimed to determine the role of subclinical zinc deficiency on sarcopenia development in patients with cirrhosis.
Patients And Methods: We enrolled 151 patients with cirrhosis and divided them into the group with normal serum zinc levels (Group N: 80-130 μg/dl; n=38) and group with subclinical zinc deficiency (Group D: <80 μg/dl; n=113). The risk factors for sarcopenia were then investigated.
Results: Group D had more sarcopenia cases than Group N (31.0% vs. 13.2%). In group D, HGS exhibited a weakly positive but significant correlation with serum zinc levels (R=0.287, p=0.00212), serum zinc levels negatively correlated with both ammonia and myostatin levels (R=-0.254, p=0.0078; R=-0.33, p<0.01), and low zinc levels were independently associated with sarcopenia development.
Conclusion: Patients with cirrhosis showing subclinical zinc deficiency have a significantly higher risk of developing sarcopenia.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8962814 | PMC |
| http://dx.doi.org/10.21873/cdp.10093 | DOI Listing |
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