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Cardiac organ chip: advances in construction and application.
Biomater Transl
November 2024
Guangdong Provincial Key Laboratory of Construction and Detection in Tissue Engineering, School of Basic Medical Science, Southern Medical University, Guangzhou, Guangdong Province, China.
Cardiovascular diseases are a leading cause of death worldwide, and effective treatment for cardiac disease has been a research focal point. Although the development of new drugs and strategies has never ceased, the existing drug development process relies primarily on rodent models such as mice, which have significant shortcomings in predicting human responses. Therefore, human-based in vitro cardiac tissue models are considered to simulate physiological and functional characteristics more effectively, advancing disease treatment and drug development.
View Article and Find Full Text PDFp-Phenylenediamines and their derived quinones: A review of their environmental fate, human exposure, and biological toxicity.
J Hazard Mater
January 2025
College of Environment and Resources, College of Carbon Neutral, Zhejiang A & F University, Hangzhou 311300, China.
p-Phenylenediamines (PPDs) are widely used as antioxidants in numerous rubber products to prevent or delay oxidation and corrosion. However, their derived quinones (PPD-Qs), generated through reactions with ozone, are ubiquitous in the environment and raise significant health and toxicity concerns. This review summarizes the current state of knowledge on environmental distribution and fate, human exposure, and biological toxicity of PPDs and PPD-Qs, and makes recommendations for future research directions.
View Article and Find Full Text PDFAreas of modernization of the system of training and certification of forensic experts in Ukraine based on the adaptation of foreign experience.
Forensic Sci Res
December 2024
Department of Political Science and Law, Kyiv National University of Construction and Architecture, Kyiv, Ukraine.
Unlabelled: The article is devoted to the study of the existing system of training and certification of forensic experts in Ukraine and to the provision of proposals for its modernization, taking into account the positive experience in the field of forensic science of the USA, UK and some countries of the European Union. In Ukraine, the procedure for the training and certification of forensic experts is determined by ministries and other central executive authorities, which manage state specialized institutions that carry out forensic activities. A study of foreign experience in the training and certification of forensic experts made it possible to identify general and specific elements, sustain the benefits of the implemented measures, and formulate priorities and guidelines.
View Article and Find Full Text PDFBridging bioengineering and nanotechnology: Bone marrow derived mesenchymal stem cell-exosome solutions for peripheral nerve injury.
World J Stem Cells
January 2025
First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, Tianjin 300381, China.
Peripheral nerve injury (PNI) is a common disease that is difficult to nerve regeneration with current therapies. Fortunately, Zou demonstrated the role and mechanism of bone marrow derived mesenchymal stem cells (BMSCs) in promoting nerve regeneration, revealing broad prospects for BMSCs transplantation in alleviating PNI. We confirmed the fact that BMSCs significantly alleviate PNI, but there are shortcomings such as low cell survival rate and immune rejection, which limit the wide application of BMSCs.
View Article and Find Full Text PDFThe integration of large-scale power electronic equipment has intensified harmonic issues in power systems. Accurate harmonic models are fundamental for evaluating and mitigating harmonic problems, but existing models still exhibit deficiencies in harmonic mechanism, model complexity and accuracy. This work proposes a calculation method of crossed frequency admittance matrix (CFAM) analytical model based on piecewise linearization, aiming to achieve accurate modeling of phase-controlled power electronic harmonic sources.
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