Safety and reliability of artificial CO2 augmentation method in comparison with standard apneic oxygenation method for brain death determination.

Introduction: The most commonly used apnea test for determination of brain death is the apneic oxygenation method. While all the commonly used apnea tests have associated complications, artificial CO augmentation has been reported to have fewer complications. However, data supporting the use of the latter method is limited.

Methods: We identified 102 patients who underwent brain death testing during the last ten years. Artificial CO augmentation apnea testing was used in 50 of these patients while 52 patients underwent standard apneic oxygenation apnea testing.

Results: No significant differences between the two groups were noted in any previously considered clinical outcomes, including hypoxemia, acidemia, or shock. However, shorter duration of apnea testing was observed in the artificial CO augmentation method suggesting its feasibility to the standard apneic oxygenation method in terms of convenience and reduction of the risk surrounding prolonged hypercapnia and hypoxemia.

Conclusion: This retrospective cohort study provides further observational evidence to support the safety of alternate apnea testing techniques with the standard apnea method for determination of brain death in adults.