AI Article Synopsis
- Synaptic vesicles are crucial for neurotransmission and must be continually replaced after they fuse with the membrane, which is influenced by neuronal activity.
- New research suggests that instead of being stably docked, vesicles can quickly switch between docking and undocking states, providing more flexibility during synaptic activity.
- The review highlights evidence for this "transient docking," its implications for synaptic function, and raises questions about what factors influence a vesicle's docking duration.
Article Abstract
As synaptic vesicles fuse, they must continually be replaced with new docked, fusion-competent vesicles to sustain neurotransmission. It has long been appreciated that vesicles are recruited to docking sites in an activity-dependent manner. However, once entering the sites, vesicles were thought to be stably docked, awaiting calcium signals. Based on recent data from electrophysiology, electron microscopy, biochemistry, and computer simulations, a picture emerges in which vesicles can rapidly and reversibly transit between docking and undocking during activity. This "transient docking" can account for many aspects of synaptic physiology. In this review, we cover recent evidence for transient docking, physiological processes at the synapse that it may support, and progress on the underlying mechanisms. We also discuss an open question: what determines for how long and whether vesicles stay docked, or eventually undock?
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9167714 | PMC |
| http://dx.doi.org/10.1016/j.conb.2022.102535 | DOI Listing |
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