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Mindfulness Training vs Recovery Support for Opioid Use, Craving, and Anxiety During Buprenorphine Treatment: A Randomized Clinical Trial.
JAMA Netw Open
January 2025
Department of Psychiatry, Harvard Medical School, Boston, Massachusetts.
Importance: During buprenorphine treatment for opioid use disorder (OUD), risk factors for opioid relapse or treatment dropout include comorbid substance use disorder, anxiety, or residual opioid craving. There is a need for a well-powered trial to evaluate virtually delivered groups, including both mindfulness and evidence-based approaches, to address these comorbidities during buprenorphine treatment.
Objective: To compare the effects of the Mindful Recovery Opioid Use Disorder Care Continuum (M-ROCC) vs active control among adults receiving buprenorphine for OUD.
Efficacy and safety of interferon-alpha 1b injection into the intervertebral foramen with ultrasonic guidance in patients with postherpetic neuralgia: study protocol for a randomized, double-blind, placebo-controlled, multicenter clinical trial.
Front Neurol
January 2025
Department of Pain Medicine, China-Japan Friendship Hospital, Beijing, China.
Purpose: Postherpetic neuralgia (PHN) is a type of refractory neuropathic pain that causes significant suffering, disability, economic loss, and medical burden. In this study, we aim to evaluate the efficacy and safety of interferon (IFN)-α1b injection into the intervertebral foramen of patients with PHN.
Patients And Methods: This is a study protocol for a randomized, double-blind placebo-controlled multicenter clinical trial.
Test-retest reliability of the Arabic version of the Pittsburgh Sleep Quality Index.
Medicine (Baltimore)
January 2025
Department of Medical Education, College of Medicine, Imam Mohammad Ibn Saud Islamic University, Riyadh, Saudi Arabia.
This study aimed to assess the test-retest reliability and validity of the Arabic version of the Pittsburgh Sleep Quality Index (A-PSQI), a 19-item sleep evaluation tool, in a population of medical students and interns in Saudi Arabia. Following a 16-person pilot study, 202 participants completed 2 A-PSQI questionnaires with a 2-week test-retest interval to avoid a carryover effect. Statistical analysis using RStudio included Cronbach alpha, Spearman rank correlation, and the intraclass correlation coefficient (ICC).
View Article and Find Full Text PDFProspective Pilot Evaluation of the Safety, Tolerability, and Efficacy of Clindamycin Phosphate 1.2%/Adapalene 0.15%/Benzoyl Peroxide 3.1% Gel plus Clascoterone 1% Cream in Adult Patients with Acne.
J Clin Aesthet Dermatol
January 2025
Ms. Swenson and Dr. Graber are with the Dermatology Institute of Boston in Boston, Massachusetts.
Background: Acne vulgaris (acne) is a common disorder with a complex, multi-faceted pathophysiology. To date, there has not been a single topical treatment that targets all aspects of acne pathophysiology (ie, increased sebum production, presence of , inflammation, and follicular hyperkeratinization). As such, topical treatments need to be utilized in combination to target all four of the major recognized pathophysiologic components in acne lesion formation.
View Article and Find Full Text PDFTwo-week Paramedic Hospital Training Augments Blood Pressure Response to Isometric Handgrip Exercise in Healthy Young Men.
Am J Physiol Regul Integr Comp Physiol
January 2025
College of Life and Health Sciences, Chubu University, Kasugai, Japan.
Persistent stressful situations can have detrimental cardiovascular effects; however, effects on the blood pressure (BP) response to exercise have not been fully examined. This study investigated the impact of a 2-week stressful situation on the exercise pressor response. Eight healthy male university paramedic trainees underwent a 2-week paramedic hospital training and a control period study.
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