AI Article Synopsis
- Intestinal Talaromyces marneffei (TM) infection is rare but has been observed in 31 HIV/AIDS patients in Guangxi, showing common symptoms like fever and abdominal lymphadenopathy.
- Most affected patients had severely low CD4 T-cell counts (<50 cells/μL), indicating a compromised immune system.
- TM was found in blood and bone marrow samples, and all patients had evidence of fungal spores in tissues, suggesting the need to consider TM infection in similar HIV-infected patients with significant gastrointestinal symptoms.
Article Abstract
Intestinal Talaromyces marneffei (TM) infection among patients with HIV/AIDS is rare. Herein, we report 31 cases of intestinal TM infection in Guangxi. Most patients exhibited fever, lymphadenectasis in the abdominal cavity, and chronic intestinal symptoms. CD4 T-cell counts <50 cells/μL were reported in 28 patients. TM was cultured from the blood of 23 patients and from the marrow of 7 patients, whereas TM-like fungal spores in the cytoplasm of tissues with erosion, ulceration, and/or polyps were found in all 31 patients. We suggest that intestinal TM infection should be considered among patients infected with HIV with extremely low CD4 T-cell counts (<50 cells/μL) who are manifesting fever, chronic gastrointestinal symptoms, and endoscopic evidence of erosion and/or ulceration.
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| http://dx.doi.org/10.1016/j.ijid.2022.03.057 | DOI Listing |
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