The apicomplexan parasite Cystoisospora suis is an enteropathogen of suckling piglets with woldwide distribution. As with all coccidian parasites, its lifecycle is characterized by asexual multiplication followed by sexual development with two morphologically distinct cell types that presumably fuse to form a zygote from which the oocyst arises. However, knowledge of the sexual development of C. suis is still limited. To complement previous in vitro studies, we analysed transcriptional profiles at three different time points of development (corresponding to asexual, immature and mature sexual stages) in vitro via RNASeq. Overall, transcription of genes encoding proteins with important roles in gametes biology, oocyst wall biosynthesis, DNA replication and axonema formation as well as proteins with important roles in merozoite biology was identified. A homologue of an oocyst wall tyrosine rich protein of Toxoplasma gondii was expressed in macrogametes and oocysts of C. suis. We evaluated inhibition of sexual development in a host-free culture for C. suis by antiserum specific to this protein to evaluate whether it could be exploited as a candidate for control strategies against C. suis. Based on these data, targets can be defined for future strategies to interrupt parasite transmission during sexual development.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8993856 | PMC |
| http://dx.doi.org/10.1038/s41598-022-09714-8 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The influence of fetal sex on antenatal maternal glucose and insulin dynamics.
Front Clin Diabetes Healthc
December 2024
Obstetric Medicine, Royal Hospital for Women, Randwick and Medicine at The University of New South Wales, Sydney, NSW, Australia.
The 'Developmental Origins of Health and Disease' (DOHaD) hypothesis postulates that exposures during critical periods of development and growth, including maternal hyperglycemia, can have significant consequences for short- and long-term health in offspring. The influence of fetal status on maternal (patho)physiology is less well understood but gaining attention. Fetal sex specifically may be an independent risk factor for a range of adverse pregnancy outcomes, including increased gestational diabetes mellitus (GDM) frequency with male fetuses in multi-ethnic populations.
View Article and Find Full Text PDFThe Digital Transformation and the Right to Health of Young Adults in Bangladesh and Colombia: A Community-Engaged Study.
Health Hum Rights
December 2024
In her 2023 report to the United Nations Human Rights Council on digital innovation, technology, and the right to health, the Special Rapporteur on the right to health underscored the positive impact of the digital transformation on young people, but also noted serious concerns, calling for greater efforts to consult and engage with youth and civil society. In our study, early-career researchers from Bangladesh and Colombia collaborated within a broader international research and advocacy project to investigate how diverse young adults experience digital health and to invite their recommendations and collaborative advocacy. Researchers held focus group discussions and interviews with young adults aged 18-30 (in Bangladesh, predominantly men; in Colombia, people living with HIV, gay men, and transgender women).
View Article and Find Full Text PDFSchistosoma sex-biased microRNAs regulate ovarian development and egg production by targeting Wnt signaling pathway.
Commun Biol
December 2024
Shanghai Tenth People's Hospital, Institute for Infectious Diseases and Vaccine Development, School of Medicine, Tongji University, Shanghai, China.
Adult Schistosoma produces a large number of eggs that play essential roles in host pathology and disease dissemination. Consequently, understanding the mechanisms of sexual maturation and egg production may open a new avenue for controlling schistosomiasis. Here, we describe that Bantam miRNA and miR-1989 regulate Wnt signaling pathway by targeting Frizzled-5/7/9, which is involved in ovarian development and oviposition.
View Article and Find Full Text PDFMT-100, a human Tie2-agonistic antibody, improves penile neurovasculature in diabetic mice via the novel target Srpx2.
Exp Mol Med
January 2025
National Research Center for Sexual Medicine and Department of Urology, Inha University College of Medicine, Incheon, Republic of Korea.
Diabetes is an incurable, chronic disease that can lead to many complications, including angiopathy, peripheral neuropathy, and erectile dysfunction (ED). The angiopoietin-Tie2 signaling pathway plays a critical role in blood vessel development, formation, remodeling, and peripheral nerve regeneration. Therefore, strategies for activating the Tie2 signaling pathway have been developed as potential therapies for neurovascular diseases.
View Article and Find Full Text PDFProtecting children against sexual abuse in youth-serving organizations: A qualitative vignette study on (potential) offenders' and therapists' views of Safeguarding Programs.
Child Abuse Negl
December 2024
Department of Forensic Psychiatry and Psychotherapy, Ulm University, Ulm, Germany.
Background: Holistic approaches to preventing child sexual abuse (CSA) such as German Safeguarding Programs integrate comprehensive analysis, intervention, prevention, and evaluation efforts and can be used to address CSA in youth-serving organizations (YSOs). To date, little is known about how adults who have committed CSA in YSOs in the past (i.e.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!