AI Article Synopsis
- Lodenafil is a PDE5 inhibitor used for erectile dysfunction, similar to medications like sildenafil and tadalafil.
- It is a prodrug that converts into two active lodenafil molecules in the body, offering better oral bioavailability than its parent compound.
- The article covers various aspects of lodenafil, including its composition, therapeutic uses, preparation methods, properties, and dosing guidelines.
Article Abstract
Lodenafil is a class of drugs called an inhibitor of PDE5 which also include a wide range of other erectile medicines, such as sildenafil, tadalafil and vardenafil. It is part of a new generation of PDE5 inhibitors that includes udenafil and avanafil. Lodenafil is a prodrug manufactured in the form of lodenafil carbonate, the carbonate dimer that divides in the body into two active drug lodenafil molecules. The oral bioavailability of this formulation is higher than that of the parent drug. This article discusses, by a critical comprehensive review of the literature on lodenafil in terms of its description, names, formulae, elemental composition, appearance, and therapeutic uses. The article also discusses the methods for preparation of lodenafil, its physical-chemical properties, analytical methods for its determination, pharmacological-toxicological properties, and dosing information.
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| http://dx.doi.org/10.1016/bs.podrm.2021.10.004 | DOI Listing |
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