AI Article Synopsis
- - Heterogeneous nuclear ribonucleoproteins C (HnRNP C) is an RNA-binding protein that plays a crucial role in the maturation and stabilization of pre-mRNAs into mRNAs, significantly impacting gene expression in cancer.
- - Dysregulation of hnRNP C has been associated with various cancers, and it interacts with important biological molecules like microRNAs, long noncoding RNAs, and double-stranded RNAs.
- - The protein's influence on processes such as alternative cleavage and polyadenylation, as well as m6A modification, varies across different cancers, making hnRNP C a potential biomarker for cancer prognosis.
Article Abstract
Heterogeneous nuclear ribonucleoproteins C (HnRNP C) is part of the hnRNP family of RNA-binding proteins. The relationship between hnRNP C and cancers has been extensively studied, and dysregulation of hnRNP C has been found in many cancers. According to existing public data, hnRNP C could promote the maturation of new heterogeneous nuclear RNAs (hnRNA s, also referred to as pre-mRNAs) into mRNAs and could stabilize mRNAs, controlling their translation. This paper reviews the regulation and dysregulation of hnRNP C in cancers. It interacts with some cancer genes and other biological molecules, such as microRNAs (miRNAs), long noncoding RNAs (lncRNAs), and double-stranded RNAs (dsRNAs). Even directly binds to them. The effects of hnRNP C on biological processes such as alternative cleavage and polyadenylation (APA) and N6-methyladenosine (m6A) modification differ among cancers. Its main function is regulating stability and level of translation of cancer genes, and the hnRNP C is regarded as a candidate biomarker and might be valuable for prognosis evaluation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8994388 | PMC |
| http://dx.doi.org/10.1186/s40364-022-00366-4 | DOI Listing |
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