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Pharmacological profiling of small molecule modulators of the TMEM16A channel and their implications for the control of artery and capillary function.
Br J Pharmacol
January 2025
Department of Pharmacology, University of Oxford, Oxford, UK.
Background And Purpose: TMEM16A chloride channels constitute a depolarising mechanism in arterial smooth muscle cells (SMCs) and contractile cerebral pericytes. TMEM16A pharmacology is incompletely defined. We elucidated the mode of action and selectivity of a recently identified positive allosteric modulator of TMEM16A (PAM_16A) and of a range of TMEM16A inhibitors.
View Article and Find Full Text PDFRevisiting the unobtrusive role of exogenous stem cells beyond neural circuits replacement in spinal cord injury repair.
Theranostics
January 2025
Department of biochemistry and molecular biology, College of Life Sciences, Central South University, Changsha, 410078, Hunan, China.
Stem cell transplantation is a promising strategy to establish neural relays in situ for spinal cord injury (SCI) repair. Recent research has reported short-term survival of exogenous cells, irrespective of immunosuppressive drugs (ISD), results in similar function recovery, though the mechanisms remain unclear. This study aims to validate this short-term repair effect and the potential mechanisms in large animals.
View Article and Find Full Text PDFInteractions of transcranial magnetic stimulation with brain oscillations: a narrative review.
Front Syst Neurosci
December 2024
Department of Neurology and Stroke, University of Tübingen, Tübingen, Germany.
Brain responses to transcranial magnetic stimulation (TMS) can be recorded with electroencephalography (EEG) and comprise TMS-evoked potentials and TMS-induced oscillations. Repetitive TMS may entrain endogenous brain oscillations. In turn, ongoing brain oscillations prior to the TMS pulse can influence the effects of the TMS pulse.
View Article and Find Full Text PDFSocial and perceptual decisions predict differences in face inversion neural correlates: Implications for development and face perception methods.
Soc Neurosci
January 2025
Department of Psychology, University of South Carolina, Columbia, SC, USA.
Article Synopsis
- Social attention helps people understand social cues and is crucial for developing complex social cognition; both automatic and purposeful attention play essential roles in this process.
- The study analyzed how different approaches to attention affected brain activity during a face inversion task, revealing no significant differences for the P1 and N170 brain markers, but differing results for P3 based on social decision-making.
- Results showed that adults and adolescents processed face perception differently, suggesting that developmental changes continue into adolescence and that task decisions can impact neural responses to faces by age.
GABA Receptors and K7 Channels as Targets for GABAergic Regulation of Acetylcholine Release in Frog Neuromuscular Junction.
Neurochem Res
November 2024
Laboratory of Biophysics of Synaptic Processes, Kazan Institute of Biochemistry and Biophysics, FRC Kazan Scientific Center of RAS, 2/31 Lobachevsky St, Kazan, 420111, Russia.
Article Synopsis
- The study investigated the effects of gamma-aminobutyric acid (GABA) and selective GABAergic ligands on acetylcholine (ACh) release at frog neuromuscular junctions using microelectrode techniques alongside fluorescent and immunohistochemical assays.
- It was found that GABA significantly reduced ACh release; however, this effect wasn't completely reversed by GABA antagonists, indicating a complex interaction.
- Additionally, GABA was shown to activate specific K7 potassium channels directly, suggesting that endogenous GABA may play a role in regulating neurotransmitter release during muscle contraction.
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