AI Article Synopsis
- Clostridioides difficile infection (CDI) frequently recurs in patients, with about 25% experiencing a relapse after initial treatment, especially if they've had a previous relapse.
- A study of 134 patients revealed that the use of prophylactic probiotics and nasogastric tube feeding were significant risk factors for the initial recurrence of CDI.
- The findings suggest that patients using prophylactic probiotics tend to have higher recurrence rates, highlighting a potential vulnerability for CDI during probiotic use.
Article Abstract
Objectives: Clostridioides difficile infection (CDI) often recurs. Approximately 25% of patients have recurrences after the initial treatment, and patients who have relapsed once are more likely to relapse. We aimed to identify the risk factors for initial CDI recurrence.
Methods: We performed a retrospective survey of patient backgrounds and treatment-related factors. Risk factors were analyzed using single and multiple logistic regression analyses.
Results: A total of 134 patients were included in the study. Prophylactic probiotic use and nasogastric tube feeding were independent risk factors for the initial recurrence of CDI. Patients using prophylactic probiotics had significantly higher recurrence rates than those not using prophylactic probiotics.
Conclusion: Prophylactic probiotic use and nasogastric tube placement may be risk factors for the initial recurrence of CDI. It is noteworthy that CDI that occurs during the use of prophylactic probiotics may be prone to recurrence.
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| http://dx.doi.org/10.1016/j.anaerobe.2022.102556 | DOI Listing |
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