An AI-assisted cryo-EM pipeline for structural studies of cellular extracts.

Structure

Institute for Medical Physics and Biophysics and Center for Soft Nanoscience (SoN), Westfälische Wilhelms Universität Münster, 48149 Münster, Germany. Electronic address:

Published: April 2022

AI Article Synopsis

  • Proteins are essential for life and usually come together in large groups to perform their roles, yet they have been traditionally studied on an individual basis in structural biology.
  • Skalidis et al. (2022) introduce a new method to identify and analyze these protein communities as intact units.
  • Their approach allows for the determination of protein structures at nearly atomic resolution, offering a more comprehensive understanding of protein interactions and functions.

Article Abstract

Proteins, the building blocks of life, often form large assemblies to perform their function but are traditionally studied separately in structural biology. In this issue of Structure, Skalidis et al. (2022) present a workflow to identify members of intact protein communities and solve their structures de novo to near-atomic resolution.

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Source
http://dx.doi.org/10.1016/j.str.2022.03.016DOI Listing

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