Stem cell-derived β cells go in monkeys.

Cell Stem Cell

Paul Langerhans Institute Dresden of the Helmholtz Center Munich at The University Hospital Carl Gustav Carus and Faculty of Medicine of the Technische Universität Dresden, Dresden 01307, Germany; Department of Medicine III, University Hospital Carl Gustav Carus, Technische Universität Dresden, Dresden 01307, Germany; Center for Diabetes Research (DZD e.V.), 85764 Neuherberg, Germany; DFG-Center for Regenerative Therapies Dresden, Technische Universität Desden, Dresden 01307, Germany. Electronic address:

Published: April 2022

Du et al. transplanted β cells derived from pluripotent stem cells in diabetic monkeys for the first time, as an intermediate stage toward clinical translation. They observed benefits unfolding over months but also observed immune rejection of the grafts by 5-6 months.

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Source
http://dx.doi.org/10.1016/j.stem.2022.03.010DOI Listing

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