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Baseline characteristics of the North American prodromal Synucleinopathy cohort.
Ann Clin Transl Neurol
April 2023
Washington University School of Medicine, St. Louis, Missouri, USA.
Objective: Rapid eye movement (REM) sleep behavior disorder (RBD) is widely considered a prodromal synucleinopathy, as most with RBD develop overt synucleinopathy within ~10 years. Accordingly, RBD offers an opportunity to test potential treatments at the earliest stages of synucleinopathy. The North American Prodromal Synucleinopathy (NAPS) Consortium has created a multisite RBD participant, primarily clinic-based cohort to better understand characteristics at diagnosis, and in future work, identify predictors of phenoconversion, develop synucleinopathy biomarkers, and enable early stage clinical trial enrollment.
View Article and Find Full Text PDFWhat Works for One May Not Work for Another: A New Warning for Modafinil.
Cureus
July 2022
Medicine, University of Maryland School of Medicine, Baltimore, USA.
Narcolepsy is a clinical syndrome of hypothalamic disorder characterized by several sleep-wake disorders. The most common features include daytime sleepiness associated with hallucinations (hypnagogic and hypnopompic hallucinations) at the transition time of sleep-wake time, cataplexy or sudden loss of muscle tone, and sleep paralysis. We present a case of a patient affected with both narcolepsy and postural orthostatic tachycardia syndrome (POTS).
View Article and Find Full Text PDFNarcolepsy and Orthostatic Intolerance in an Adult With Ehlers-Danlos Syndrome.
Prim Care Companion CNS Disord
April 2022
King Edward Medical University, Lahore, Pakistan.
Novel vaccine safety issues and areas that would benefit from further research.
BMJ Glob Health
May 2021
Essential Medicines and Health Products, Organisation Mondiale de la Sante, Geneve, Switzerland.
Vaccine licensure requires a very high safety standard and vaccines routinely used are very safe. Vaccine safety monitoring prelicensure and postlicensure enables continual assessment to ensure the benefits outweigh the risks and, when safety problems arise, they are quickly identified, characterised and further problems prevented when possible. We review five vaccine safety case studies: (1) dengue vaccine and enhanced dengue disease, (2) pandemic influenza vaccine and narcolepsy, (3) rotavirus vaccine and intussusception, (4) human papillomavirus vaccine and postural orthostatic tachycardia syndrome and complex regional pain syndrome, and (5) RTS,S/adjuvant system 01 malaria vaccine and meningitis, cerebral malaria, female mortality and rebound severe malaria.
View Article and Find Full Text PDFComorbidity of chronic fatigue syndrome, postural tachycardia syndrome, and narcolepsy with 5,10-methylenetetrahydrofolate reductase (MTHFR) mutation in an adolescent: a case report.
Chin Med J (Engl)
March 2021
Department of Pediatrics, Peking University First Hospital, Beijing 100034, China.
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