AI Article Synopsis
- Our bodies create various electrophilic species that can interact with and label certain proteins within cells, leading to ongoing discussions about their signaling functions.
- Researchers are starting to recognize that these electrophiles might significantly alter cellular signaling pathways at regular levels.
- This Perspective highlights recent findings from our lab about the context-specific regulation of proteins by electrophiles and explores their potential impact on precision medicine, moving beyond their previously understood harmful effects.
Article Abstract
Our bodies produce a host of electrophilic species that can label specific endogenous proteins in cells. The signaling roles of these molecules are under active debate. However, in our opinion, it is becoming increasingly likely that electrophiles can rewire cellular signaling processes at endogenous levels. Attention is turning more to understanding how nuanced electrophile signaling in cells is. In this Perspective, we describe recent work from our laboratory that has started to inform on different levels of context-specific regulation of proteins by electrophiles. We discuss the relevance of these data to the field and to the broader application of electrophile signaling to precision medicine development, beyond the traditional views of their pleiotropic cytotoxic roles.
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| http://dx.doi.org/10.1021/acs.chemrestox.2c00006 | DOI Listing |
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