AI Article Synopsis
- A new flavanone-flavonol dimer named gnidiflavanone-flavonol and 10 other known compounds were isolated from the roots of a plant in the Thymelaeceae family.
- The structures of these compounds were determined using advanced methods like NMR and mass spectrometry, with some compounds being reported for the first time from this plant family.
- In terms of biological activity, the crude extract and isolated compounds were tested for antimicrobial and antiplasmodial effects, with two compounds showing promising antiplasmodial activity against both chloroquine-sensitive and resistant strains.
Article Abstract
A new 3,8''-flavanone-flavonol dimer gnidiflavanone-flavonol () and 10 known compounds (-), including four rare primula-type flavones -, were isolated from the roots of . Compounds - and were reported for the first time from the plant family Thymelaeceae. Structures of the isolated compounds were established by spectroscopic data, including 1D and 2D NMR (COSY, HMBC, HSQC and ROESY) and mass spectrometry, as well as by the comparison with literature data. The crude roots extract and isolated compounds were evaluated for antimicrobial and antiplasmodial activities. Among isolated compounds, 6-hydroxyflavone () and 6--acetylflavone () showed antiplasmodial activity against chloroquine-sensitive (D6) and chloroquine-resistant (W2) strains of .
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| http://dx.doi.org/10.1080/14786419.2022.2062349 | DOI Listing |
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