Refractory Methamphetamine-Induced Psychosis: An Emerging Crisis in Rural America and the Role of Amantadine in Therapeutics.

In the last decade, methamphetamine (MA) use has substantially increased in rural America. These changes in the epidemiological trends could be attributed to the restricted availability of opioids after measures against the opioid epidemic were enforced. The availability of cheaper alternatives, such as fake prescriptions mixed with fentanyl, is a few among the many recent developments in the ongoing mental health and substance abuse crisis in rural America. A serious clinical effect of MA use is psychosis, which inadvertently has stretched mental health services. In recent times, the atypical clinical presentations of these psychotic episodes with a refractory course have challenged clinicians. Hence, the knowledge of its unique pharmacodynamics, neurotoxicity, similarities with schizophrenia amid the evolving empirical evidence is critical to addressing this unique conundrum.