AI Article Synopsis
- - The study examined the relationship between mold exposure, allergic reactions (IgE sensitization), inflammation, and respiratory issues in 46 mold-exposed individuals and 23 non-exposed individuals, using questionnaires for assessment.
- - Results showed that 41% of those exposed had elevated specific IgE levels to a mold mixture compared to 17% in non-exposed individuals; exposed asthmatics showed the highest sensitization at 55%.
- - A notable finding was lower levels of a protein (CC16) in the serum of exposed subjects, particularly asthmatics, indicating that specific IgE to molds is a significant marker for diagnosing mold-related respiratory symptoms.
Article Abstract
The associations of mold exposure, IgE-mediated sensitization, inflammatory markers, and respiratory symptoms were analyzed in 46 exposed and 23 non-exposed individuals. Both exposure and clinical symptoms were assessed by questionnaire. Specific (s)IgE to mold mixture (mx1) was significantly higher and found more frequently in exposed (41%) than non-exposed individuals (17%), which was not observed for sIgG to mold mix (Gmx6). Notably, exposed asthmatics were more frequently sensitized to molds (55%) compared to exposed non-asthmatics (18%). In addition, the serum concentrations of club cell protein (CC16) were significantly lower in exposed subjects, especially in asthmatics. Positive associations were observed among mold sensitization, asthma, and mold exposure, but not in subjects with predominantly environmental sensitizations without mold sensitization. Thus, sIgE to mx1 but not sIgG to Gmx6 is a useful diagnostic marker to verify mold-associated respiratory symptoms.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8982061 | PMC |
| http://dx.doi.org/10.5414/ALX02298E | DOI Listing |
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