AI Article Synopsis
- TREM-1 is a protein found on various immune and endothelial cells, crucial for innate immunity and involved in both infectious and non-infectious inflammation.
- It promotes inflammation by enhancing lipid accumulation and the expression of inflammatory factors, which contributes to conditions like atherosclerosis.
- The review discusses how inhibiting TREM-1 can help stabilize atherosclerotic plaques and reduce inflammation, potentially improving the disease's progression.
Article Abstract
Triggering receptor expressed on myeloid cells-1 (TREM-1) is a transmembrane protein expressed on endothelial cells, white blood cells, smooth muscle cells and platelets. TREM-1 plays an important role in innate immunity. TREM-1 activation pathways are implicated both in sepsis and in non-infectious inflammatory conditions, including atherosclerosis. TREM-1 enhances the subendothelial lipid accumulation and expression of pro-inflammatory cytokines and matrix-degrading enzymes, thereby promoting inflammation and plaque destabilization. TREM-1 inhibitors attenuate the inflammatory process in the atherosclerotic plaque, leading to plaque stabilization. This review focuses on the role of TREM-1 in the pathophysiology of atherosclerosis and the effects of TREM-1 inhibition in the natural history of the disease.
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| http://dx.doi.org/10.1016/j.pharmthera.2022.108182 | DOI Listing |
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