Review of historic article: Ebashi, S & Endo, M. 1968 Calcium Ion and Muscle Contraction. Progress in Biophysics and Molecular Biology, 18, 123-183.

The 1968 review article on Calcium ion and muscle contraction by Setsuro Ebashi and Makoto Endo is one of the highest cited in the journal since it was required reading in the early days of understanding what triggers contraction of the myofilaments. It correctly identified the major steps in excitation-contraction coupling and still inspires mathematical models of muscle activity today. It also successfully identified the role of troponin.