AI Article Synopsis
- - An efficient protocol for hydroarylation of ynamides using hydroxyarenes has been created, which is highly selective and requires minimal resources.
- - The process involves low catalyst loading, mild conditions, and uses widely available starting materials, making it practical for various applications.
- - The method allows for easy scaling and diverse functionalization of the resulting enamide products, enhancing its attractiveness for real-world use.
Article Abstract
An atom-economic protocol for the efficient and highly chemo- and stereoselective -hydroarylation of ynamides with hydroxyarenes catalyzed by B(CF) has been developed. Use of readily available starting materials, low catalyst loading, mild reaction conditions, a broad substrate scope, ease of scale-up, and versatile functionalizations of the enamide products make this approach very practical and attractive.
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| http://dx.doi.org/10.1021/acs.orglett.2c00574 | DOI Listing |
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