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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11524654 | PMC |
| http://dx.doi.org/10.1002/adma.202201543 | DOI Listing |
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A Self-Powered Piezo-Bioelectric Device Regulates Tendon Repair-Associated Signaling Pathways through Modulation of Mechanosensitive Ion Channels.
Adv Mater
October 2021
CÚRAM SFI Research Centre for Medical Devices, National University of Ireland, Galway, H91W2TY, Ireland.
Tendon disease constitutes an unmet clinical need and remains a critical challenge in the field of orthopaedic surgery. Innovative solutions are required to overcome the limitations of current tendon grafting approaches, and bioelectronic therapies show promise in treating musculoskeletal diseases, accelerating functional recovery through the activation of tissue regeneration-specific signaling pathways. Self-powered bioelectronic devices, particularly piezoelectric materials, represent a paradigm shift in biomedicine, negating the need for battery or external powering and complementing existing mechanotherapy to accelerate the repair processes.
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