[Incorporation Monitoring of Staff using I-131 and Lu-177 in a Nuclear Medicine Ward].

Nuklearmedizin

Strahlenschutz und Medizinische Physik, Medizinische Hochschule Hannover, Hannover, Germany.

Published: August 2022

Objectives: In addition to the well-established therapy with iodine-131, treatments with lutetium-177 are increasingly being performed on an inpatient basis in Germany. All of these treatments have be taken into account when assessing the potential internal dose and for incorporation monitoring of personnel. This article describes the experience with and the results of incorporation monitoring of staff of a nuclear medicine ward of a university hospital in Germany.

Methods: Personnel working in a nuclear medicine ward was regularly measured using a whole body counter. In total, 234 measurements were performed over a period of 12 months. Incorporation factors were determined considering activities handled or applied to patients in the respective time period.

Results: In approx. 74 % of measurements, no incorporations was found. In the remaining measurements, activity was detected. Assuming incorporation, the maximum effective dose would be less than 0.15 mSv per measurement. The incorporation factors determined in this work were in the order of magnitude of 10 for all groups except for personnel performing radiochemical quality control. For this group, only an upper limit of the incorporation factor of 10 can be specified.

Conclusion: The risk of incorporating radiactivity can be considered low for personnel working in a nuclear medicine ward. An incorporation factor of 10 is appropriate for medical, nursing, and cleaning staff and personnel performing radiochemical syntheses.

Download full-text PDF

Source
http://dx.doi.org/10.1055/a-1759-1940DOI Listing

Publication Analysis

Top Keywords

nuclear medicine
16
medicine ward
12
monitoring staff
8
incorporation monitoring
8
personnel working
8
working nuclear
8
incorporation factors
8
factors determined
8
personnel performing
8
performing radiochemical
8

Similar Publications

Monolithic U-shaped crystal design for TOF-DOI detectors: a flat top vs. a tapered top.

Biomed Phys Eng Express

January 2025

Advanced Nuclear Medicine Science, National Institute of Radiological Sciences, 4-9-1 Anagawa, Inage-ku, Chiba 263-8555, JAPAN, Chiba, 263-8555, JAPAN.

For brain-dedicated positron emission tomography (PET) scanners, depth-of-interaction (DOI) information is essential to achieve uniform spatial resolution across the field-of-view (FOV) by minimizing parallax error. Time-of-flight (TOF) information can enhance the image quality. In this study, we proposed a novel monolithic U-shaped crystal design that had a tapered geometry to achieve good coincidence timing resolution (CTR) and DOI resolution simultaneously.

View Article and Find Full Text PDF

Purpose: Recent clinical advances with the approval of antibody-drug conjugates targeting Trop-2 such as sacituzumab-govitecan and datopotomab-deruxtecan have garnered tremendous interest for their therapeutic efficacy in numerous tumor types including breast and lung cancers. ImmunoPET can stratify tumor avidity, clarifying patient eligibility for ADC therapy as well as a diagnostic companion during therapy. Slow antibody circulation requires days to reach optimal imaging timepoints.

View Article and Find Full Text PDF

Background: Ubiquitination and deubiquitination are involved in the progression of human diseases, including acute pneumonia. In this study, we aimed to explore the functions of ubiquitin-specific peptidase 9X-linked (USP9X) in lipopolysaccharide (LPS)-treated WI-38 cells. Methods: WI-38 cells were treated with LPS to induce the cellular damage and inflammation.

View Article and Find Full Text PDF

In Alzheimer's disease (AD), amyloid-β (Aβ) triggers the aggregation and spreading of tau pathology, which drives neurodegeneration and cognitive decline. However, the pathophysiological link between Aβ and tau remains unclear, which hinders therapeutic efforts to attenuate Aβ-related tau accumulation. Aβ has been found to trigger neuronal hyperactivity and hyperconnectivity, and preclinical research has shown that tau spreads across connected neurons in an activity-dependent manner.

View Article and Find Full Text PDF

Advanced cardiac imaging modalities have revolutionized the field of cardiovascular medicine, offering invaluable tools for both diagnosis and the management of a wide spectrum of cardiovascular diseases. These imaging methods, including echocardiography, cardiac computed tomography (CT), computed tomography angiography (CTA), cardiac magnetic resonance imaging (MRI), nuclear imaging, and fluoroscopy, offer various approaches to evaluate both the structure and function of the heart. This article provides an overview of imaging modalities for primary care physicians, highlighting their types, advantages, limitations and clinical uses.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!