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http://dx.doi.org/10.1523/JNEUROSCI.2196-21.2022 | DOI Listing |
Cells
October 2024
Aix-Marseille University, CNRS, ISM, 13009 Marseille, France.
Complement C5a protein has been shown to play a major role in tissue regeneration through interaction with its receptor (C5aR) on target cells. Expression of this receptor has been reported in the nervous system which, upon injury, has no treatment to restore the lost functions. This work aimed at investigating the Complement C5a effect on axonal growth after axotomy in vitro.
View Article and Find Full Text PDFExp Neurol
December 2024
Key Laboratory of Neuroregeneration of Jiangsu and Ministry of Education, Affiliated Traditional Chinese Medicine Hospital and Medical School, Co-Innovation Center of Neuroregeneration, Nantong University, Nantong 226001, Jiangsu, China. Electronic address:
Multilayer dense myelin tissue provides insulating space and nutritional support for axons in healthy spinal cord tissue. Oligodendrocyte precursor cells (OPCs) are the main glial cells that complement myelin loss in the central nervous system and play an important role in the repair of spinal cord injury (SCI). However, the regulation of axonal remyelination after SCI is still insufficient.
View Article and Find Full Text PDFJ Nanobiotechnology
August 2024
Key Laboratory of CNS Regeneration (Ministry of Education), Guangdong Key Laboratory of Non-human Primate Research, Guangdong-Hongkong-Macau CNS Regeneration Institute of Jinan University, Guangzhou, 510632, P. R. China.
Amyotrophic lateral sclerosis (ALS) is a fatal disease characterized by progressive motoneuron degeneration, and effective clinical treatments are lacking. In this study, we evaluated whether intranasal delivery of mesenchymal stem cell-derived small extracellular vesicles (sEVs) is a strategy for ALS therapy using SOD1 mice. In vivo tracing showed that intranasally-delivered sEVs entered the central nervous system and were extensively taken up by spinal neurons and some microglia.
View Article and Find Full Text PDFBMC Complement Med Ther
August 2024
Fujian Medical Universtity Union Hospital, Fuzhou, Fujian Province, People's Republic of China.
Background: Salidroside is the major bioactive and pharmacological active substance in Rhodiola rosea L. It has been reported to have neuroprotective effects on cerebral ischemia/reperfusion (I/R). However, whether salidroside can enhance neural regeneration after cerebral I/R is still unknown.
View Article and Find Full Text PDFCNS Neurosci Ther
July 2024
State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, China.
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