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| http://dx.doi.org/10.4212/cjhp.v75i2.3069 | DOI Listing |
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Paracetamol, its metabolites, and their transfer between maternal circulation and fetal brain in mono- and combination therapies.
Pharmacol Rep
January 2025
Department of Neuroscience, School of Translational Medicine, Monash University, Melbourne, VIC, 3004, Australia.
Background: Due to its availability and perceived safety, paracetamol is recommended even during pregnancy and for neonates. It is used frequently alone or in combination with other drugs required for the treatment of various chronic conditions. The aim of this study was to investigate potential effects of drug interactions on paracetamol metabolism and its placental transfer and entry into the developing brain.
View Article and Find Full Text PDFThe relationship between different ventricular rate control levels and cardiac remodeling in early persistent atrial fibrillation: a prospective cohort study.
Front Cardiovasc Med
January 2025
Department of Cardiovascular Medicine, First Affiliated Hospital of Zhengzhou University, Zhengzhou, China.
Background: Atrial fibrillation (AF) is a prevalent cardiac arrhythmia, with ventricular rate control being a critical therapeutic target. However, the optimal range for ventricular rate control remains unclear. Additionally, the relationship between different levels of ventricular rate control and cardiac remodeling in patients with atrial fibrillation remains unclear.
View Article and Find Full Text PDFArticle Synopsis
- The study examines how chronic exposure to digoxin affects locomotor activity and brain chemistry in zebrafish.
- Zebrafish were housed in groups and exposed to 2 μM of digoxin for a week, resulting in increased hyperactivity and decreased anxiety in a novel environment test.
- The findings reveal significant changes in brain monoamine levels, indicating that cardiotonic steroids like digoxin can influence neurotransmission, which might have implications for neuropsychiatric conditions.
Chronic Constrictive Pericarditis in Northeast India: A 10-Year Single-Center Study of Demographic and Clinical Profiles.
Cureus
November 2024
Department of Pathology, All India Institute of Medical Sciences, Guwahati, Guwahati, IND.
Article Synopsis
- Chronic constrictive pericarditis (CCP) is a disease marked by the thickening of the pericardium, leading to heart function issues, with a focus on patient demographics and clinical profiles in Northeast India over a decade.
- The study analyzed 42 CCP patients between 2011 and 2020, highlighting a high prevalence in younger individuals and a significant history of tuberculosis among participants.
- Symptoms included dyspnea and physical exam findings such as edema and hepatomegaly; imaging revealed notable heart structural changes, emphasizing the need for better diagnosis and management in the region.
Pediatric Chronic Heart Failure: Age-Specific Considerations of Medical Therapy.
Physiol Res
November 2024
Children's Heart Centre, Second Faculty of Medicine, Charles University in Prague and Motol University Hospital, Prague, Czech Republic.
Chronic heart failure (CHF) is a rare entity in children but carries a burden of high mortality and morbidity. Medical treatment of pediatric CHF is largely based on guidelines for the adult population. In contrast to adults, evidence for the efficacy of medications in treating CHF in children is sparse.
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