AI Article Synopsis
- Circular RNAs (circRNAs) are key noncoding RNAs that regulate various biological processes, making their study essential for understanding their roles in health and disease.
- A review of circRNA literature from 2000 to 2021 revealed a significant increase in publications, with a concentration of research from China and notable contributions from Germany, the USA, and others, highlighting international collaboration.
- The focus of circRNA research has shifted over time, now emphasizing their mechanisms in diseases like cancer, with promising future directions in applying circRNAs to disease understanding and treatment.
Article Abstract
Background And Purpose: Circular RNAs (circRNAs) are a big group of members of the noncoding RNA family following long non-coding RNA and microRNA. They play a regulatory role in many biological processes. Analyzing their current research status and future development trends is conducive to a more comprehensive understanding of circRNAs and contributes to the dedication to the biological field.
Methods: The literature on circRNA from 2000 to 2021 in the Web of Science Core Collection of the Web of Science database with "circular RNA" as the subject was searched. R Studio's Bibliometrix package and biblioshiny software were used for publication trend analysis, citation analysis, keyword analysis, author analysis, research institution analysis, source analysis, country analysis, and collaboration analysis for all documents and highly cited documents.
Results: From 2000 to 2021, 3,186 circRNA-related articles were published worldwide, of which 193 were highly cited. The number of published articles had shown an explosive increase after 2013. These articles were mainly from Chinese research institutions and authors, but the country with the highest average number of citations per year in highly cited documents was Germany. Scientific research institutions came from countries represented by Germany, USA, China, Australia and Canada all had different degrees of cooperation. The theme and key points of the research had evolved over time from expression to the role and mechanism of circRNA in diseases, especially in cancer. CDR1as, circFOXO3, circHIPK3, circITCH, circMTO1, circSMARCA5 and circZNF609 are circRNAs that are mainly studied currently, their studies mainly involve cell biology, biological functions and cancer. The future research direction and trend would still be the application of circRNA in diseases.
Conclusion: The basic situation and development trend of circRNA related research we described provide a direction for future research.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8956961 | PMC |
| http://dx.doi.org/10.1016/j.ncrna.2022.03.001 | DOI Listing |
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