AI Article Synopsis
- - The study investigated the relationship between tau PET biomarker [F]AV-1451 and episodic memory issues in adults with Down syndrome, building on the amyloid/tau/neurodegeneration (AT[N]) model.
- - Researchers analyzed data from 123 non-demented adults with Down syndrome, using various memory tests and tau and amyloid beta PET assessments to gauge their cognitive performance.
- - Results showed that high tau levels were linked to poorer episodic memory, particularly in participants with elevated amyloid beta, indicating that high tau could signal early signs of Alzheimer's disease in individuals with Down syndrome.
Article Abstract
Introduction: Drawing on the amyloid/tau/neurodegeneration (AT[N]) model, the study examined whether the tau positron emission tomography (PET) biomarker [F]AV-1451 was associated with episodic memory problems beyond what was predicted by the amyloid beta (Aβ) PET in Down syndrome (DS).
Methods: Data from 123 non-demented adults with DS ( = 47 years, standard deviation = 6.34) were analyzed. The Cued Recall Test assessed episodic memory. Tau PET standardized update value ratio (SUVR) was assessed across Braak regions as continuous and binary (high tau [T] vs. low tau [T]) variable. Global PET Aβ SUVR was assessed as binary variable (Aβ- vs. Aβ+).
Results: In models adjusting for controls, tau SUVR was negatively associated with episodic memory performance in the Aβ+ but not Aβ- group. The Aβ+/T group evidenced significantly worse episodic memory than the Aβ+/T group.
Discussion: Similar to late-onset and autosomal dominant Alzheimer's disease (AD), high tau was an indicator of early prodromal AD in DS.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976157 | PMC |
| http://dx.doi.org/10.1002/dad2.12256 | DOI Listing |
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