AI Article Synopsis
- Perinatal brain injury is a leading cause of cerebral palsy, which affects motor function, and understanding how it impacts early brain development, specifically the corticospinal tract (CST), is crucial.
- The research involves a protocol that combines transcranial magnetic stimulation and MRI to monitor brain development and motor skills in infants aged 3 to 24 months following brain injuries.
- The goal is to find bioindicators of motor outcomes to enhance early detection and intervention strategies for infants suffering from perinatal stroke or related conditions.
Article Abstract
Purpose: Perinatal brain injury is a primary cause of cerebral palsy, a condition resulting in lifelong motor impairment. Infancy is an important period of motor system development, including development of the corticospinal tract (CST), the primary pathway for cortical movement control. The interaction between perinatal stroke recovery, CST organization, and resultant motor outcome in infants is not well understood.
Methods: Here, we present a protocol for multimodal longitudinal assessment of brain development and motor function following perinatal brain injury using transcranial magnetic stimulation and magnetic resonance imaging to noninvasively measure CST functional and structural integrity across multiple time points in infants 3 to 24 months of age. We will further assess the association between cortical excitability, integrity, and motor function.
Discussion: This protocol will identify bioindicators of motor outcome and neuroplasticity and subsequently inform early detection, diagnosis, and intervention strategies for infants with perinatal stroke, brain bleeds, and related diagnoses.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9200232 | PMC |
| http://dx.doi.org/10.1097/PEP.0000000000000886 | DOI Listing |
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