AI Article Synopsis
- The nail plate is a key structure in the nail apparatus, highly keratinized and challenging for experimental study.
- Different types of nail consistency were identified through pressure tests on the nail plate.
- Analysis revealed that hard consistency nails have a higher presence of keratin 17 than soft consistency nails, which could aid in diagnosing nail disorders and systemic diseases.
Article Abstract
The nail plate is one of the essential structures of the nail apparatus and is highly keratinized, making it difficult to handle this tissue experimentally. Different types of nail consistency were identified by applying distal pressure to the nail plate. To analyze the relationship between the keratins expressed in the nail plate and nail consistency, we chose a sample of 32 adult individuals (age 49.81±3.21 y) with the same number of each sex, who had a similar percentage of nail consistency types (56.25% hard consistency nails and 43.75% soft consistency nails). Immunohistochemical analyses showed that hard consistency nails contain more keratin 17 than soft consistency nails (P=0.026). These novel results allow nail consistency to be defined by the differential expression of keratins in the nail plate, and have potential clinical implications for the diagnosis of possible nail disorders and/or systemic disease.
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