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Inactivation of the SLC25A1 gene during embryogenesis induces a unique senescence program controlled by p53.
Cell Death Differ
December 2024
Georgetown University Medical Center, Lombardi Comprehensive Cancer Center, Washington, D.C., USA.
Germline inactivating mutations of the SLC25A1 gene contribute to various human disorders, including Velocardiofacial (VCFS), DiGeorge (DGS) syndromes and combined D/L-2-hydroxyglutaric aciduria (D/L-2HGA), a severe systemic disease characterized by the accumulation of 2-hydroxyglutaric acid (2HG). The mechanisms by which SLC25A1 loss leads to these syndromes remain largely unclear. Here, we describe a mouse model of SLC25A1 deficiency that mimics human VCFS/DGS and D/L-2HGA.
View Article and Find Full Text PDFGreen Cities, Healthier Children: The Effect of Expanding Urban Green Space on Body Weight for Primary School Starters.
Health Econ
December 2024
Faculty of Business, Economics and Social Sciences, University of Hamburg, Hamburg, Germany.
The discussion on tackling childhood obesity is often centered around fostering physical activity. A potential relationship yet overlooked could run from providing the proper environment for healthy lifestyles to reduced weight problems. A unique quasi-experimental setting of transforming former airport grounds to a large urban green space allows me to apply a difference-in-differences approach within an intention-to-treat framework, comparing several weight outcomes of residential children to children living further away before and after park opening.
View Article and Find Full Text PDFAssessment of Myocardial Perfusion in Patients After CABG: An Update and Clinical Implications.
Semin Nucl Med
December 2024
Mid-America Heart Institute and the Saint-Lukes Health System, University of Missouri - Kansas City, Kansas, MO. Electronic address:
Stress radionuclide myocardial perfusion imaging (MPI) has been well-established as a useful modality for assessing the status of the coronary circulation in post-coronary artery bypass graft (CABG) patients. CABG by itself escalates progression of atherosclerosis or thrombosis in bypassed native coronary arteries. In most cases MPI will be employed in post-CABG patients who are experiencing symptoms.
View Article and Find Full Text PDFNovel concept for the healthy population influencing factors.
Front Public Health
December 2024
School of Management Engineering and Business, Hebei University of Engineering, Handan, China.
In the rapid urbanization process in China, due to reasons such as employment, education, and family reunification, the number of mobile population without registered residence in the local area has increased significantly. By 2020, the group had a population of 276 million, accounting for over 20% of the total population, making significant contributions to urban economic development and resource optimization. However, the health status of migrant populations is affected by unique issues such as occupational risks and socio-economic disparities, which play an important role in personal welfare, social stability, and sustainable economic growth.
View Article and Find Full Text PDFA comprehensive and bias-free machine learning approach for risk prediction of preeclampsia with severe features in a nulliparous study cohort.
BMC Pregnancy Childbirth
December 2024
Department of Computer Science, Columbia University, 1214 Amsterdam Ave, 721 Schapiro CEPSR, New York, NY, 10027, USA.
Preeclampsia is one of the leading causes of maternal morbidity, with consequences during and after pregnancy. Because of its diverse clinical presentation, preeclampsia is an adverse pregnancy outcome that is uniquely challenging to predict and manage. In this paper, we developed racial bias-free machine learning models that predict the onset of preeclampsia with severe features or eclampsia at discrete time points in a nulliparous pregnant study cohort.
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