Nonsmall cell lung cancer (NSCLC) is one of the most common malignancies and needs novel and effective chemotherapy. In this study, our purpose is to explore the anticancer effects of 2-methoxy-5((3,4,5-trimethosyphenyl) seleninyl) phenol (SQ) on human NSCLC (A549 and H460) cells. We found that SQ suppressed the proliferation of NSCLC cells in time- and dose-dependent manners, and blocked the cells at G2/M phase, which was relevant to microtubule depolymerization. Additionally, SQ induced A549 and H460 cell apoptosis by activating the mitochondrial apoptotic pathway. Further, we demonstrated that SQ enhanced the generation of reactive oxygen species (ROS), and pretreatment with N-acetyl- L-cysteine (NAC) attenuated SQ-induced cell apoptosis. Meanwhile, SQ mediated-ROS generation caused DNA damage in A549 and H460 cells. Our data also revealed that SQ-induced apoptosis was correlated with the inhibition of mouse double minute 2 (MDM2) in A549 and H460 cells. In summary, our research indicates that the novel compound SQ has great potential for therapeutic treatment of NSCLC in future.

Download full-text PDF

Source
http://dx.doi.org/10.1002/jbt.23066DOI Listing

Publication Analysis

Top Keywords

a549 h460
16
h460 cells
12
2-methoxy-5345-trimethosyphenyl seleninyl
8
seleninyl phenol
8
nsclc cells
8
mitochondrial apoptotic
8
apoptotic pathway
8
cell apoptosis
8
cells
6
nsclc
5

Similar Publications

Lung cancer continues to be the second most common cancer diagnosed and the main cause of cancer-related death globally, which requires novel and effective treatment strategies. When considering treatment options, non-small cell lung cancer (NSCLC) remained a challenge, seeking new therapeutic strategies High-power microwave (HPM) progressions have facilitated the advancement of new technologies as well as improvements to those already in use. The impact of HPM on NSCLC has not been investigated before.

View Article and Find Full Text PDF

Decoding the prognostic landscape of LUAD: the interplay between N-methyladenosine modification and immune microenvironment.

Front Immunol

December 2024

State Key Laboratory of Trauma and Chemical Poisoning, Department of Stem Cell and Regenerative Medicine, Daping Hospital, Army Medical University, Chongqing, China.

Background: To determine the role of N-methyladenosine (mA) modification in the tumor immune microenvironment (TIME), as well as their association with lung adenocarcinoma (LUAD).

Methods: Consensus clustering was performed to identify the subgroups with distinct immune or mA modification patterns using profiles from TCGA. A risk score model was constructed using least absolute shrinkage and selection operator regression and validated in two independent cohorts and LUAD tissue microarrays.

View Article and Find Full Text PDF

Objectives: Immune checkpoint inhibitors (ICIs) have demonstrated potential in inhibiting the growth of malignant pleural mesothelioma (MPM), and their efficacy is associated with the expression of programmed death-ligand 1(PD-L1). This study evaluated a PD-L1-targeted nanoprobe for detecting PD-L1 expression in a nude mouse model of malignant pleural mesothelioma (MPM).

Methods: A PD-L1-binding peptide (WL-12) was conjugated with superparamagnetic iron oxide nanoparticles (SPIONs) to create the nanoprobe WL-12@Fe₃O₄.

View Article and Find Full Text PDF

Polyhydroxyalkanes from Sieb. et Zucc.

Nat Prod Res

December 2024

Shaanxi Key Laboratory of Research and Application of "Taibai Qi Yao", School of Pharmacy, Shaanxi University of Chinese Medicine, Xianyang, Shaanxi, P. R. China.

Four polyhydroxyalkanes were isolated from the CHCl part of , including two new ones, (2,3)-3-isopropylpent-3-ene-1,2,5-triol () and (4,2)-4,5-dihydroxy-2,3-dimethylpent-2-enoic acid (); as well as one new natural product, 3-methylbut-3-ene-1,2-diol () and one known compound, 4-methyl-3-methylenepentane-1,2-diol (). The structures were determined by physicochemical properties and spectroscopic methods including 1D, 2D NMR, IR, HR-ESI-MS, and ECD data. The cytotoxic activity of compounds against the human cancer lines A549, H460, and HepG2 cell lines of the isolated compounds was evaluated by the CCK8 method.

View Article and Find Full Text PDF

Despite the proven inhibitory effects of drugs targeting vascular endothelial growth factor receptor 2 (VEGFR2) on solid tumors, including non-small cell lung cancer (NSCLC), the development of anti-NSCLC drugs solely targeting VEGFR2 still faces risks such as off-target effects and limited efficacy. This study aims to develop a novel fingerprint-enhanced graph attention convolutional network (FnGATGCN) model for predicting the activity of anti-NSCLC drugs. Employing a multimodal fusion strategy, the model integrates a feature extraction layer that comprises molecular graph feature extraction and molecular fingerprint feature extraction.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!