Background: Despite the association of genetic factors with falls, balance, and lower extremity functioning, interaction of the angiotensin-converting enzyme () gene insertion/deletion (I/D) polymorphism with fear of falling (FOF) in relation to stepping performance has, to the best of our knowledge, not been investigated in older adults.
Objective: The purpose of this study was to examine the interaction effects of the I/D polymorphism with FOF in relation to stepping performance in older adults.
Methods: Eighty-eight community-dwelling adults 60 years or older participated in a cross-sectional observational study. Participants completed tests of rapid and distance stepping, and self-reported FOF (yes/no). Participants provided saliva for genotyping. General linear models evaluated genotype × FOF interaction effects in relation to stepping performance. The α level was set at 0.05.
Results: The I/D polymorphism exhibited significant interaction effects ( for interactions 0.002 ≤ ≤ .04) with FOF in relation to stepping speed. Relationships between FOF and stepping speed varied among genotypes. The insertion/insertion (II) genotype was significantly associated ( = .01) with slow stepping in individuals with, but not without FOF ( > .05).
Conclusion: Variation in relationships between FOF and stepping speed among genotypes suggests a role for the I/D polymorphism in modifying relationships between FOF and stepping speed in older adults. The association of the II genotype with slow stepping performance in individuals with, but not without FOF, suggests that older adults with the II genotype and FOF may be at increased risk for poor stepping performance and associated functional declines.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1080/09593985.2022.2056861 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
A Deep Learning-Based Framework Oriented to Pathological Gait Recognition with Inertial Sensors.
Sensors (Basel)
January 2025
Department of Electrical and Information Engineering (DEI), Polytechnic University of Bari, Via E. Orabona, 4, 70125 Bari, Italy.
Abnormal locomotor patterns may occur in case of either motor damages or neurological conditions, thus potentially jeopardizing an individual's safety. Pathological gait recognition (PGR) is a research field that aims to discriminate among different walking patterns. A PGR-oriented system may benefit from the simulation of gait disorders by healthy subjects, since the acquisition of actual pathological gaits would require either a higher experimental time or a larger sample size.
View Article and Find Full Text PDFEffects of High-Intensity Motor Learning and Dietary Supplementation on Motor Skill-Related Physical Fitness in Thin Ethiopian Children Aged 5 to 7 Years: An Exploratory Pilot Cluster-Randomized Trial.
Nutrients
December 2024
Rehabilitation Research Centre (REVAL), Rehabilitation Sciences and Physiotherapy, Hasselt University, Wetenschapspark 7, 3590 Diepenbeek, Belgium.
Background: Malnutrition has extensive consequences, affecting multiple levels of functioning, including motor skill impairments. However, current interventions have mainly focused on dietary treatment, often neglecting motor impairments and relying solely on clinical and anthropometric indicators to assess treatment response. This study aims to bridge this gap by examining the combined effect of ready-to-use supplementary food (RUSF) and high-intensity motor learning (HiML) on motor skill-related physical fitness in children with moderate thinness (MT).
View Article and Find Full Text PDFUsing behavioural science to improve antibiotic stewardship in Canadian long-term care homes: Protocol for a multi-center cluster randomized quality improvement study.
Can Commun Dis Rep
January 2025
Data, Surveillance and Foresight Branch, Public Health Agency of Canada, Ottawa, ON.
Background: Antimicrobial resistance (AMR) is associated with significant human and financial costs, particularly among vulnerable populations like older adults living in long-term care homes (LTCHs). Urinary tract infection (UTI) is the leading indication for antibiotic use in this population, with some estimates suggesting that up to 70% of these prescriptions may be avoidable.
Objective: The purpose of this study is to develop and test novel behavioural science-informed antimicrobial stewardship (AMS) quality improvement strategies in Canadian LTCHs, which aim to decrease unnecessary testing and treatment for residents who lack the minimum clinical signs and symptoms of UTI.
Effect of the surface morphology of alkaline-earth metal oxides on the oxidative coupling of methane.
Sci Technol Adv Mater
December 2024
Department of Life, Environment and Applied Chemistry, Fukuoka Institute of Technology, Fukuoka, Japan.
Alkaline-earth metal oxides with the rocksalt structure, which are simple ionic solids, have attracted attention in attempts to gain fundamental insights into the properties of metal oxides. The surfaces of alkaline-earth metal oxides are considered promising catalysts for the oxidative coupling of methane (OCM); however, the development of such catalysts remains a central research topic. In this paper, we performed first-principles calculations to investigate the ability of four alkaline-earth metal oxides (MgO, CaO, SrO, and BaO) to catalyze the OCM.
View Article and Find Full Text PDFThe Influence of Aging on Hip Abductor Muscle Torque, Power, Velocity and the Association With Lower Limb Physical Function.
J Geriatr Phys Ther
November 2024
Department of Physical Therapy and Rehabilitation Science, University of Maryland School of Medicine, Baltimore, Maryland.
Background And Purpose: Muscle strength, power, and mass decline with aging, leading to functional loss highly correlated with balance and falls in older adults. Lower limb muscle function is critical for fall prevention in older adults, and hip abductor force and rapid force development have been shown to be important during stepping tasks. However, it remains unclear whether hip abductor muscle function changes with aging.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!