HS is the third gas transmitter affecting the growth, reproduction and survival of cancer cells. However, the HS anticancer and antitumor mechanism still needs to be further studied. Here, FHS-1 was synthesized utilizing excited-state intramolecular proton transfer to detect HS in MCF-7 cells, and investigated the effects of varying concentrations NaHS on apoptosis. The study found that FHS-1 detects HS levels with high selectivity and pH stability and that HS may regulate apoptosis in MCF-7 cells through the p53/mTOR/STAT3 pathway. Researching the influence of HS on apoptosis can serve as a theoretical foundation for future research into HS-related anticancer medicines, and the HS probe can be used as an effective cancer screening tool.
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