Background: Presently India is the second most populous country in the world with an estimated population of 1.4 billion people and has recently been affected by COVID-19 pandemic and subsequent mutant viral outbreak. To date, India has administered its population with over 1.30 billion cumulative doses of COVID-19 vaccine. The consequences of COVID-19 vaccination on the outbreak in India has not been reported until now. Therefore, we probed to assess the impact of COVID-19 outbreak in India from December 2019 to December 2021.
Methods: Indian COVID-19 related data were extracted from "ourworldindata.org" and "cowin.gov.in" databases. The incidence rate of COVID-19 per million people was calculated and other parameters such as new cases, positive rate, reproduction rate, new death and stringency index values were extracted from the database for statistical analysis.
Results: Data indicate that the COVID-19 positive rate declined as the number of vaccinations rose over time. The Pearson correlation values between new cases and the cumulative percentage of vaccination or the percentage of fully vaccinated population showed no correlation (P < 0.01). COVID-19 vaccination has significantly decreased the R-value and positive rate of SARS-CoV-2 in India (P < 0.01). Furthermore, containment measures showed no correlation with the incidence rate of SARS-CoV-2 in India which may be in contradictory to the global trends.
Conclusion: Vaccination against COVID-19 was efficacious in the control of the SARS-CoV-2 outbreak and the decrease in the positive rate. Further, the containment measures had no effect on the spread of COVID-19 infection in India, thus far.
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http://dx.doi.org/10.1016/j.amsu.2022.103554 | DOI Listing |
Background: Kyasanur forest disease virus (KFDV) is a tick-borne flavivirus causing debilitating and potentially fatal disease in people in the Western Ghats region of India. The transmission cycle is complex, involving multiple vector and host species, but there are significant gaps in ecological knowledge. Empirical data on pathogen-vector-host interactions and incrimination have not been updated since the last century, despite significant local changes in land use and the expansion of KFD to new areas.
View Article and Find Full Text PDFJ Immunol Methods
January 2025
ICAR-Indian Veterinary Research Institute, Bangalore, Karnataka 560024, India.
Bluetongue (BT) is a vector-borne viral disease of multiple domestic and wild ruminants across the globe. The VP7 protein of bluetongue virus (BTV) is the major immune-dominant structural protein that is conserved across the BTV serotypes and therefore, targeted for the development of immuno-diagnostics for BT. In this study, full-length recombinant VP7 protein (rVP7) of BTV-1 was expressed in Trochoplusia ni derived insect cells (Tn5) using codon-optimized synthetic gene construct through baculovirus expression system.
View Article and Find Full Text PDFLancet Glob Health
January 2025
TB Modelling Group, TB Centre, and Centre for Mathematical Modelling of Infectious Diseases, Department of Infectious Disease Epidemiology, London School of Hygiene & Tropical Medicine, London, UK.
Background: Approximately 20% of global tuberculosis incidence is attributable to undernutrition, increasing to more than a third in India. Targeting nutritional interventions to tuberculosis-affected households is a policy priority, but understanding of epidemiological and economic impacts is limited. We aimed to estimate the population-level epidemiological and economic effect of such an intervention.
View Article and Find Full Text PDFLancet Gastroenterol Hepatol
January 2025
Division of Medical Oncology, National Cancer Centre Singapore, Singapore. Electronic address:
Background: Aspirin is a simple, globally available medication that has been shown to reduce the incidence of colorectal cancer. We aimed to evaluate the safety and efficacy of aspirin in the secondary prevention of colorectal cancer.
Methods: This phase 3, randomised, double-blind, placebo-controlled trial was conducted at 66 centres across 11 countries and territories (ten in Asia-Pacific; one in the Middle East).
PLoS One
January 2025
Department of Community Medicine and School of Public Health, Post Graduate Institute of Medical Education and Research, Chandigarh, India.
Background: Non-communicable diseases (NCDs) are governed by a cluster of unhealthy behaviours and their determinants, like tobacco and alcohol, unhealthy diet, lack of physical activity, overweight and obesity, pollution (air, water, and soil), and stress. Regulation of these unhealthy behaviours plays a crucial role in blood pressure control among individuals on hypertensive treatment, especially those suffering from uncontrolled hypertension. Hence, the present study aims at identifying the unhealthy behaviours associated with uncontrolled hypertension.
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