AI Article Synopsis

  • Pregnancy can put significant physiological stress on women, often leading to complications like peripartum cardiomyopathy, which is a serious cardiovascular condition that increases maternal morbidity and mortality.
  • The prevalence of this condition varies by geography and family history, indicating a need for more research to improve understanding and outcomes.
  • Effective treatment often involves medical management options, including new drugs currently in clinical trials, bromocriptine therapy, and anticoagulant combinations, which can help manage the condition's progression.

Article Abstract

Pregnancy is considered one of the most delicate conditions for the woman and her fetus, rendering physiological stress on her body. Sometimes, this leads to unwelcomed incidences of certain systemic disorders which further complicate the course of pregnancy. Cardiovascular conditions associated with pregnancy have major morbidity amongst the general population. Peripartum cardiomyopathy, one such condition associated with cardiac dysfunction during pregnancy, is one of the major causes of increased morbidity and mortality in pregnant women. It has been the leading cause of non-obstetric maternal mortality. Due to the stress on the cardiovascular system, further functioning of the body in the milieu gets compromised and thus, the occurrence of fetomaternal mortality is not rare in the prognosis of this condition. Certain studies have noted not only familial but also geographical variations in the prevalence of peripartum cardiomyopathy in certain areas. Although the occurrence of the condition is quite common, there still needs to be a better understanding of this topic for avoiding the abysmal prognosis of this pathology. A peculiar presentation on the electrogram is needed to make an accurate diagnosis of the condition. The therapeutic options of this condition, particularly incline towards medical management. Various new drugs have been formulated and are in clinical trials for testing their effectiveness. Bromocriptine therapy, along with the neoadjuvant combination of anticoagulant drugs and non-pharmacological measures, makes a good treatment regimen that helps avert the progressive pathology. In this article, we discuss the knowledge regarding the etiology, factors contributing to the severity, pathogenesis, treatment options, and the particular outcomes of the therapy.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8976525PMC
http://dx.doi.org/10.7759/cureus.22813DOI Listing

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