AI Article Synopsis
- An induced pluripotent stem cell (iPSC) line named SJHi001-A was created from a diabetic patient with a specific mutation in the GCGR gene.
- The patient's father's cell line, SJHi002-A, was also developed as a control and shows no diabetes or mutation.
- Both iPSC lines maintained normal genetics, expressed markers indicative of pluripotency, and were capable of differentiating into the three primary germ layers when tested in vivo.
Article Abstract
Induced pluripotent stem cell (iPSC) line, SJHi001-A, was generated from a diabetic patient carrying a heterozygous c.G248A mutation in GCGR gene that generated the p.W83X. The PBMCs from her father (no diabetes and no mutation site) were also prepared into iPSC (SJHi002-A) as a control. Both two cell lines had normal karyotype, expressed pluripotency markers and could differentiate into the three germ layers in vivo.
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| http://dx.doi.org/10.1016/j.scr.2022.102745 | DOI Listing |
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