AI Article Synopsis
- Researchers evaluated the prognostic value of the systemic inflammation response index (SIRI) and Epstein-Barr virus (EBV) DNA levels in children and adolescents with advanced nasopharyngeal carcinoma (CALANPC).
- A study of 205 patients used recursive partitioning analysis (RPA) to identify low- and high-risk groups based on overall survival (OS), revealing that higher levels of SIRI and EBV DNA correlated with poorer survival outcomes.
- The findings indicated that combining SIRI with EBV DNA improves risk assessment for patients, outperforming traditional TNM staging systems in predicting overall survival.
Article Abstract
Background: To assess the prognostic value of the systemic inflammation response index (SIRI) combined with plasma load of Epstein-Barr virus (EBV) DNA in children and adolescents with locoregionally advanced nasopharyngeal carcinoma (CALANPC).
Methods: A total of 205 consecutive patients with CALANPC were enrolled. We used recursive partitioning analysis (RPA) to classify patients into various risk groups, with a primary endpoint of overall survival (OS).
Results: Elevated SIRI (≥1.53) and EBV DNA (≥4000 copy/ml) were significantly associated with inferior OS in CALANPC. RPA categorized patients into low- and high-risk groups based on prognostic factors. Survival curves showed excellent discrimination in OS (95.3% vs 77.6%; p < 0.001) between the low- and high-risk groups. A significant improvement was confirmed using the prognostic methods for conventional TNM staging systems (p < 0.05).
Conclusions: The combination of SIRI with EBV DNA provided a more detailed understanding of patient risks, and enhanced risk discrimination in CALANPC.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/hed.27033 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!