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| http://dx.doi.org/10.1080/14656566.2022.2060738 | DOI Listing |
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Background: While a number of recent anti-amyloid antibodies demonstrated a robust reduction of amyloid biomarkers in clinical trials, the impact on functional improvement is much more variable. We hypothesize that this larger variability is driven by comedications, common genotype variants and underlying tau pathology.
Method: In a previously calibrated computational neuroscience model of ADAS-Cog, we implemented the effect of soluble amyloid monomers and oligomers on glutamate and nicotinic AChR neurotransmission and the effect of intracellular tau oligomers on voltage-gated Na and K+ channels and synaptic density.
Buckwheat responds to co-exposure to PLA microplastics and Pb by regulating the synthesis of unsaturated fatty acids and jasmonates.
J Hazard Mater
December 2024
College of Resources, Sichuan Agricultural University, Chengdu 611130, China. Electronic address:
Polylactic acid (PLA) microplastics (MPs) and lead (Pb) co-contamination, an emerging co-contamination, may profoundly impact plant growth. We aimed to evaluate the effects of PLA-MPs and Pb on buckwheat growth and physiology and to elucidate the underlying molecular mechanisms through an integrated transcriptomic and metabolomic approach. PLA-MPs alone reduced buckwheat biomass by 26.
View Article and Find Full Text PDFPersonalized nutrition and precision medicine in perimenopausal women: A minireview of genetic polymorphisms COMT, FUT2, and MTHFR.
Clinics (Sao Paulo)
December 2024
Laboratório de Produtos e Derivados Naturais, Laboratório de Investigação Médica-26 (LIM-26), Departamento de Cirurgia, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP 01246903, Brazil; Laboratório de Parasitologia Médica (LIM-46), Departamento de Doenças Infecciosas e Parasitárias, Faculdade de Medicina da Universidade de São Paulo, São Paulo, SP 05403-000, Brazil; Botânio Pesquisa e Desenvolvimento Ltda, São Paulo, SP 05545010, Brazil. Electronic address:
This mini-review explores the potential of precision medicine and personalized nutrition in addressing health challenges faced by perimenopausal women, focusing on the role of genetic polymorphisms in key metabolic pathways. Specifically focus on the single nucleotide polymorphisms (SNPs) in the COMT, FUT2, and MTHFR genes, which influence neurotransmitter metabolism, gut microbiota composition, and folate homeostasis, respectively. These polymorphisms are critical in modulating hormonal fluctuations, metabolic imbalances, and nutrient absorption during perimenopause.
View Article and Find Full Text PDFCOMT ValMet polymorphism protects the impact of a mother's history of childhood trauma on emotional and behavioural problems in preschool children.
Eur J Neurosci
December 2024
Post-Graduated Program in Health and Behavior, Catholic University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
Article Synopsis
- Childhood trauma negatively affects mental health and can be passed down to future generations, impacting the emotional and behavioral issues of children.
- The study analyzed 310 preschool-aged children to see how maternal childhood trauma interacted with genetic factors, specifically the COMT ValMet variant, and assessed behavioral problems using established questionnaires.
- Results showed that while maternal trauma generally increases behavioral issues in children, those with the Val/Met genotype are less prone to certain problems compared to those with other genetic variants, highlighting the importance of both trauma and genetics in child development.
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