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| http://dx.doi.org/10.34067/KID.0006232021 | DOI Listing |
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The Persistence of Antibiotic Resistance in Observational Studies: Is It Really Due to Differences in Sub-Populations Rather than Antibiotic Use?
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January 2025
Independent Researcher, Melbourne, VIC 3000, Australia.
: The carriage of resistant bacteria and prior antimicrobial treatment are related, but in an individual, this diminishes over time. To better manage antimicrobial resistance risks, it is crucial that we better untangle any lasting impact of antibiotic use compared to other factors. This understanding is essential for informing antimicrobial stewardship programs and to better manage other important factors that likely contribute to persistently higher rates of antimicrobial resistance in different populations.
View Article and Find Full Text PDFUntangling the complex mechanisms associated with Alzheimer's disease in elderly patients using high-throughput RNA sequencing data and next-generation knowledge discovery methods: Focus on potential gene signatures and drugs for dementia.
Heliyon
January 2025
Institute of Genomic Medicine Sciences, Faculty of Applied Medical Sciences, King Abdulaziz University, Jeddah, 21589, Saudi Arabia.
Objectives: Alzheimer's disease (AD) is a complex neurodegenerative disorder that primarily affects elderly individuals. This study aimed to elucidate the intricate mechanisms underlying AD in elderly patients compared with healthy aged individuals using high-throughput RNA sequencing (RNA-seq) data and next-generation knowledge discovery methods (NGKD), with a focus on identifying potential therapeutic agents.
Methods: High-throughput RNA-seq data were obtained from the Gene Expression Omnibus (GEO) database (accession number: GSE104704).
Molecular and cellular dynamics of the developing human neocortex.
Nature
January 2025
The Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, University of California San Francisco, San Francisco, CA, USA.
The development of the human neocortex is highly dynamic, involving complex cellular trajectories controlled by gene regulation. Here we collected paired single-nucleus chromatin accessibility and transcriptome data from 38 human neocortical samples encompassing both the prefrontal cortex and the primary visual cortex. These samples span five main developmental stages, ranging from the first trimester to adolescence.
View Article and Find Full Text PDFThe effects of childhood maltreatment and social support on the trajectories of depressive symptoms from adolescence to young adulthood.
Child Abuse Negl
February 2025
Clarkson University, Potsdam, NY. USA.
Background: Depression is one of the most common mental health concerns among adolescents and young adults. Childhood maltreatment is a particularly potent risk factor for the subsequent development of depressive symptoms. Meanwhile, social support has been identified as a robust protective factor against depressive symptoms.
View Article and Find Full Text PDFUnlabelled: Neurodegenerative disorders, including Alzheimer's disease and AD-related dementias (AD/ADRD), pose significant challenges to health care systems globally, particularly in Africa. With the advances in medical technology and research capabilities, especially in next-generation sequencing and imaging, vast amounts of data have been generated from AD/ADRD research. Given that the greatest increase in AD/ADRD prevalence is expected to occur in Africa, it is critical to establish comprehensive bioinformatics training programs to help African scientists leverage existing data and collect additional information to untangle AD/ADRD heterogeneity in African populations.
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