RAD51 loading onto chromatin is a key step during the homologous recombination (HR) repair. We recently reported a new mode of RAD51 regulation, which is mediated by TOPORS E3 SUMO ligase and RAD51 SUMOylation. ATM/ATR-induced phosphorylation of TOPORS is necessary for this event, revealing a new role of these master DNA damage response kinases in HR repair.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8973377 | PMC |
| http://dx.doi.org/10.1080/23723556.2022.2054263 | DOI Listing |
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