Syntheses, Characterizations, and Inhibition Activities Against Coxsackievirus B3 of Iodobenzoic Hydrazide Functionalized Hexamolybdates.

A class of iodobenzoyldiazenido-functionalized POMs (TBA) [MoO(=N=NCOAr)] (Ar = Ph--I ; Ph--I ; Ph--I ; Ph-3,4-I ; Ph-2,3,5-I (TBA = tetrabutylammonium) were prepared the refluxing reaction of -octamolybdates, DCC, and corresponding hydrazides in dry acetonitrile. Their structures were determined by Fourier-transform infrared spectroscopy, ultraviolet-visible spectra, X-ray photoelectron spectroscopy, hydrogen-1 nuclear magnetic resonance, and high-resolution mass spectrometry. Research on the biological activity of title compounds shows that , , and demonstrate potent inhibitory activity against coxsackievirus B3 and low cytotoxic activity against Hep-2 cell lines. The covalent linkage between the iodobenzoyldiazenido components and POMs can enhance the molecular inhibitory efficiency of iodobenzohydrazides.