Rough set theory, presented by Pawlak in 1981, is one of the most well-known methods for communicating ambiguity by estimating an item based on some knowledge rather than membership. The concept of a rough function and its convexity and differentiability in regard to its boundary region are discussed in this work. The boundary notion is also used to present a new form of rough programming issue and its solutions. Finally, numerical examples are provided to demonstrate the proposed method and emphasize its advantages over other approaches.
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http://dx.doi.org/10.1155/2022/8662289 | DOI Listing |
J Clin Oncol
January 2025
Department of Clinical Oncology, State Key Laboratory of Translational Oncology, Chinese University of China, Shatin, Hong Kong Special Administrative Region, China.
Purpose: Mobocertinib is an oral epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor that targets exon 20 insertion (ex20ins) mutations in non-small cell lung cancer (NSCLC). This open-label, phase III trial (EXCLAIM-2: ClinicalTrials.gov identifier: NCT04129502) compared mobocertinib versus platinum-based chemotherapy as first-line treatment of ex20ins+ advanced/metastatic NSCLC.
View Article and Find Full Text PDFJ Comput Assist Tomogr
January 2025
Centre for Biomedical Engineering, Indian Institute of Technology Delhi.
Objective: Early diagnosis of primary and metastatic lung nodules is critical for effective therapeutic planning. Manual delineation of lung nodules is not time-efficient and is prone to human error as well as interobserver and intraobserver variability. This study aimed to address the unmet need for an open-source computer-aided detection (CAD) system for 3D segmentation of lung and metastatic lung nodules along with radiomic feature extraction.
View Article and Find Full Text PDFSci Rep
January 2025
College of Hydraulic and Civil Engineering, Xinjiang Agricultural University, 311 East Nongda Rd, Urumqi, 830052, China.
Water conveyance channels in cold and arid regions pass through several saline-alkali soil areas. Canal water leakage exacerbates the salt expansion traits of such soil, damaging canal slope lining structures. To investigate the mechanical properties of saline clay, this study conducted indoor tests, including direct shear, compression, and permeation tests, and scanning electron microscopy (SEM) analysis of soil samples from typical sites.
View Article and Find Full Text PDFSci Rep
January 2025
School of Computer Science and Technology, Liaocheng University, Liaocheng, 252000, Shandong, P.R. China.
Copy number variation (CNV) is an important part of human genetic variations, which is associated with various kinds of diseases. To tackle the limitations of traditional CNV detection methods, such as restricted detection types, high error rates, and challenges in precisely identifying the location of variant breakpoints, a new method called MSCNV (copy number variations detection method for multi-strategies integration based on a one-class support vector machine model) is proposed. MSCNV establishes a multi-signal channel that integrates three strategies: read depth, split read, and read pair.
View Article and Find Full Text PDFJ R Soc Interface
January 2025
Department of Engineering Mechanics, KTH Royal Institute of Technology, Stockholm, Sweden.
Culturing living cells in three-dimensional environments increases the biological relevance of laboratory experiments, but requires solutes to overcome a diffusion barrier to reach the centre of cellular constructs. We present a theoretical and numerical investigation that brings a mechanistic understanding of how microfluidic culture conditions, including chamber size, inlet fluid velocity and spatial confinement, affect solute distribution within three-dimensional cellular constructs. Contact with the chamber substrate reduces the maximally achievable construct radius by 15%.
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