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Combinatorial Treatment with Praziquantel and Curcumin Reduces Parasite Burden and Clonorchiasis-Associated Pathologies in Rats.
Pharmaceutics
December 2024
Department of Medical Zoology, School of Medicine, Kyung Hee University, Seoul 02447, Republic of Korea.
: Clonorchiasis is a foodborne parasitic disease that can lead to severe biliary fibrosis and cholangiocarcinoma. While praziquantel (PZQ) is available for clonorchiasis treatment, it cannot revert the histopathological damage incurred through parasite-induced fibrosis. Curcumin (CUR) is an emerging experimental drug possessing anti-inflammatory and fibrosis-alleviating effects, thus signifying its potential as an anthelmintic drug.
View Article and Find Full Text PDFSystematic review on the cost of seasonal malaria chemoprevention (SMC).
Malar J
December 2024
Management Sciences for Health, Arlington, VA, USA.
Background: Implemented in 17 countries to date, seasonal malaria chemoprevention (SMC) is a recommended strategy to prevent childhood malaria in areas with seasonal transmission of P. falciparum through monthly administration of antimalarial medicines. Understanding the costs and resource requirements of SMC delivery is necessary for effective planning and resource allocation.
View Article and Find Full Text PDFDetermining household out of pocket payments, incidence of catastrophic expenditures and impoverishment among patients with malaria in Zambia's path towards Universal Health Coverage.
PLoS One
December 2024
School of Public Health and Population, University of British Columbia, Vancouver, British Columbia, Canada.
Background: The World Health Organisation (WHO) estimates that about 3.2 billion people which is nearly half of the world's population are at risk of malaria. Annually about 216 million cases and 445,000 deaths of malaria occur globally.
View Article and Find Full Text PDFCost of the national malaria control program and cost-effectiveness of indoor residual spraying and insecticide-treated bed net interventions in two districts of Madagascar.
Cost Eff Resour Alloc
December 2024
Institut Pasteur de Madagascar, Antananarivo, Madagascar.
Article Synopsis
- * This study analyzed the costs and effectiveness of two malaria control interventions—Insecticide-Treated Nets (ITNs) and Indoor Residual Spraying (IRS)—in two districts, comparing their cost-effectiveness ratios (CERs) to determine the better intervention.
- * From 2009 to 2013, the National Malaria Control Program (NMCP) cost approximately USD 45.4 million annually, with IRS being significantly more expensive than ITNs; the CER for IRS was about six times higher than that of ITNs, indicating that ITNs might be
Estimates of resource use in the public-sector health-care system and the effect of strengthening health-care services in Malawi during 2015-19: a modelling study (Thanzi La Onse).
Lancet Glob Health
January 2025
Institute for Global Health, University College London, London, UK.
Background: In all health-care systems, decisions need to be made regarding allocation of available resources. Evidence is needed for these decisions, especially in low-income countries. We aimed to estimate how health-care resources provided by the public sector were used in Malawi during 2015-19 and to estimate the effects of strengthening health-care services.
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