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Intraventricular Hemorrhage and Survival, Multimorbidity, and Neurodevelopment.
JAMA Netw Open
January 2025
Population Policy and Practice, Great Ormond Street UCL Institute of Child Health, London, United Kingdom.
Importance: Intraventricular hemorrhage (IVH) has proven to be a challenging and enduring complication of prematurity. However, its association with neurodevelopment across the spectrum of IVH severity, independent of prematurity, and in the context of contemporary care remains uncertain.
Objective: To evaluate national trends in IVH diagnosis and the association with survival and neurodevelopmental outcomes at 2 years of age.
Effect of tumor microenvironment in pancreatic cancer on the loss of β-cell mass: implications for type 3c diabetes.
J Gastroenterol
January 2025
Department of Endocrinology and Metabolism, Zhongshan Hospital, Fudan University, 180 Fenglin Road, Shanghai, 200032, People's Republic of China.
Background: To explore the complex interactions between the tumor microenvironment (TME) of pancreatic ductal adenocarcinoma (PDAC) and the loss of β-cell mass, further elucidating the mechanisms of type 3c diabetes mellitus (T3cDM) onset.
Methods: Single-cell RNA sequencing was employed to analyze the PDAC TME, identifying cell interactions and gene expression changes of endocrine cells. Pathological changes and paraneoplastic islets were assessed in the proximal paratumor (PP) and distal paratumor (DP).
Identification of hydrogeochemical processes in shallow groundwater using multivariate statistical analysis and inverse geochemical modeling.
Environ Monit Assess
January 2025
College of Earth Sciences, Guilin University of Technology, Guilin, 541006, China.
Identifying key factors that control the chemical evolution of groundwater along groundwater flow direction is essential in ensuring the safety of groundwater resources in upper watersheds and lower plains. In this study, the ion ratio, multivariate statistics, and inverse geochemical modeling were used to investigate and explore the chemical characteristics of groundwater and factors driving the formation of groundwater components in the plain area of Deyang City, China. The chemical type of groundwater in the area was dominated by the HCO-Ca type, and the variation in groundwater chemical composition was mainly affected by water-rock interaction and human interference.
View Article and Find Full Text PDFContent validation of the nursing diagnosis "Adult Disuse Syndrome": A quantitative study.
Int J Nurs Knowl
January 2025
Health Sciences Department, Public University of Navarre (UPNA), Pamplona, Spain.
Purpose: This study aimed to establish the content validity of the proposed nursing diagnosis (ND) "Adult Disuse Syndrome" and all its components.
Method: This is an exploratory descriptive study of diagnostic content validation under Fehring's proposal. Forty three expert nurses with clinical, teaching, and research experience analyzed the components of the diagnosis.
Reduced expression of the serotonin transporter impacts mitochondria in a sexually dimorphic manner.
Biochem Biophys Rep
March 2025
School of Biological Sciences, Victoria University of Wellington Kelburn, Parade, 6012, Wellington, New Zealand.
Neuropsychiatric and neurodevelopmental disorders are complex conditions that arise from a variety of interacting genetic and environmental factors. Among these factors, altered serotonergic signalling and mitochondrial dysfunction are strongly implicated, with a growing body of evidence to suggesting that serotonergic signalling is an important regulator of mitochondrial biogenesis. The serotonin transporter (SERT) functions to regulate synaptic 5-HT, and human allelic variants of the serotonin reuptake transporter-linked polymorphic region (5-HTTLPR) are associated with reduced SERT expression and increased susceptibility for developing neuropsychiatric disorders.
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