AI Article Synopsis
- The review focuses on recent developments regarding anaphylaxis in children, covering new definitions, diagnosis methods, and treatments.
- A 2019 update from WAO proposes broader criteria for diagnosing anaphylaxis to encourage quicker use of adrenaline, which is crucial in treatment and preventing severe reactions.
- Key risk factors for fatal anaphylaxis in children are identified, and advancements in diagnostics and therapies are highlighted, alongside updates to the International Classification of Diseases (ICD-11) for better coding of anaphylaxis cases.
Article Abstract
The objective of the review is to present recent updates on anaphylaxis in paediatric population worldwide. The article summarizes the results of epidemiological studies, diagnostic methods and treatments. We present a new WAO definition of anaphylaxis (2019), which broader criteria excluding dermal symptoms should facilitate faster life-saving adrenaline use. Adrenaline remains the best treatment to manage severe symptoms and to prevent biphasic reactions. There is ongoing effort to increase adrenaline use, such as modified autoinjectors, individual training, and diversified dosing. There are five independent risk factors of lethal anaphylaxis in children, including history of asthma, almost immediate onset of symptoms, unwell appearance, tachycardia and hypotension. We also report improvements in diagnostics, like component-resolved diagnostics, and novel therapies stimulating immunotolerance. We signal the development of ICD-11 with updated coding of anaphylaxis, which corresponds better to clinical observations.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8953896 | PMC |
| http://dx.doi.org/10.5114/ada.2021.103327 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!