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Bone and Nerve Response to Sciatic Compression Neuropathy in a Rabbit Model.
J Orthop Res
January 2025
Department of Orthopaedic Surgery, Montefiore Einstein, Bronx, New York, USA.
Compression neuropathy is a prevalent medical condition, including common types such as carpal tunnel syndrome, cubital tunnel syndrome, sciatica, and many others. While the neurological consequences are well understood, the effects on bone properties and the potential downstream impact on fracture risk remain less clear. This study aimed to assess the influence of compressive neuropathy on bone properties using a rabbit model of sciatic nerve compression.
View Article and Find Full Text PDFAssessment of the piriformis muscle and piriformis syndrome via Web of Science database: A bibliometric analysis.
Medicine (Baltimore)
November 2024
Department of Anatomy, Cukurova University Faculty of Medicine, Adana, Turkey.
Background: Piriformis syndrome, which is seen as the cause of 0.3% to 6% of low back pain, is a painful condition that occurs as a result of compression of the piriformis muscle on the sciatic nerve. Although there are many studies in the literature about piriformis syndrome, no bibliometric analysis has been found.
View Article and Find Full Text PDFOlive oil and castor oil-based self-nanoemulsifying drug delivery system of flurbiprofen can relieve peripheral pain and inflammation through reduction of oxidative stress and inflammatory biomarkers: a comprehensive formulation and pharmacological insights.
Inflammopharmacology
January 2025
Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad, 45210, Pakistan.
Flurbiprofen (FBP) is poorly water-soluble BCS class II drug with anti-inflammatory and analgesic effects, used to treat arthritis and degenerative joint diseases. This study was aimed to develop SNEDDS loaded with FBP. Six SNEDDS using two oils olive oil (F, F, F) and castor oil (F, F, F) with three different Smix ratios consisting of Tween 20 and PEG 400 (1:1, 1:2, 2:1) were prepared and characterized.
View Article and Find Full Text PDFPseudo-Sciatica Pain Due to a Biceps Femoris Muscle Tear.
Cureus
November 2024
Intervention and Musculoskeletal Rehabilitation, Centro de Reabilitação do Norte, Unidade Local de Saúde (ULS) Gaia/Espinho, Vila Nova de Gaia, PRT.
Hamstring injuries (HSIs) are common among athletes, particularly in high-speed sports, and are frequently associated with prolonged recovery periods and a high recurrence rate. This study presents a 36-year-old male with sciatica-like symptoms following an acute hamstring tear during an amateur football match. The patient experienced this pain two weeks after the injury, suggesting potential sciatic nerve involvement.
View Article and Find Full Text PDFBlood expression of NADK2 as a diagnostic biomarker for sciatica.
iScience
November 2024
Department of Spine Surgery, the First Affiliated Hospital, Zhejiang University School of Medicine, Hanzhou, China.
Sciatica is characterized by radiating pain along the sciatic nerve, with a lifetime prevalence of up to 43%. This study explored blood biomarkers for sciatica using transcriptomic microarray data (GSE124272 and GSE150408). Differential gene expression analysis identified NADK2 as a potential diagnostic biomarker.
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