This is the first report to describe dose dependency in the effects of tolvaptan treatment for autosomal dominant polycystic kidney disease.The weight-adjusted average daily dose of tolvaptan was found to be a factor that significantly affected the change in eGFR.If a patient shows tolerance, increasing the tolvaptan dose to the maximum should be considered.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8786106PMC
http://dx.doi.org/10.34067/KID.0007342020DOI Listing

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