The coronavirus disease 2019 (COVID-19) pandemic had grounded the world to a standstill. As the disease continues to rage two years on, it is apparent that effective therapeutics are critical for a successful endemic living with COVID-19. A dearth in suitable antivirals has prompted researchers and healthcare professionals to investigate existing and developmental drugs against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Although some of these drugs initially appeared to be promising for the treatment of COVID-19, they were ultimately found to be ineffective. In this review, we provide a retrospective analysis on the merits and limitations of some of these drugs that were tested against SARS-CoV-2 as well as those used for adjuvant therapy. While many of these drugs are no longer part of our arsenal for the treatment of COVID-19, important lessons can be learnt. The recent inclusion of molnupiravir and Paxlovid™ as treatment options for COVID-19 represent our best hope to date for endemic living with COVID-19. Our viewpoints on these two drugs and their prospects as current and future antiviral agents will also be provided.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC8970615 | PMC |
| http://dx.doi.org/10.1016/j.phrs.2022.106201 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Screening for Crimean-Congo Haemorrhagic Fever Virus antibodies in humans living in an endemic area of Spain.
Enferm Infecc Microbiol Clin (Engl Ed)
January 2025
Servicio de Medicina Interna, Unidad de Infecciosas, HUS, IBSAL, e-INTRO, CIETUS, Universidad de Salamanca, Salamanca, Spain. Electronic address:
Introduction: Crimean-Congo haemorrhagic fever (CCHF) is an emerging tick-borne viral disease. It has been described in Spain in both ticks and humans. Until July 2024 most cases have been described in the central-western part of the Iberian Peninsula.
View Article and Find Full Text PDFNeglected class A carbapenemases: Systematic review of IMI/NmcA and FRI from a One Health perspective.
Sci Total Environ
January 2025
Laboratoire de Bactériologie, Centre Hospitalier Universitaire de Montpellier, Montpellier, France; UMR MIVEGEC, Université de Montpellier, IRD, CNRS, Montpellier, France.
Carbapenemase-producing Enterobacterales are pathogens classified as a critical priority by the World Health Organization and a burden on human health worldwide. IMI, NmcA, and FRI are under-detected class A carbapenemases that have been reported in the human, animal and environmental compartments, particularly these last 5 years. Bacteria producing these carbapenemases have been mostly identified in digestive carriage screenings, but they are also involved in severe infections, such as bacteremia.
View Article and Find Full Text PDFLiving - and dying - with Schizophrenia in Australia.
Australas Psychiatry
January 2025
National Centre for Epidemiology and Population Health, School of Medicine and Psychology, The Australian National University, Acton, ACT, Australia.
Evaluation of Bayesian Maximum Entropy Data Fusion Approaches to Estimate Styrene, Benzene, Toluene, Ethylbenzene, and Xylenes and to Inform Epidemiological Analyses in the US Gulf States.
Environ Sci Technol
January 2025
Department of Environmental Sciences & Engineering, University of North Carolina, Chapel Hill, North Carolina 27599, United States.
The Gulf States are home to industries emitting styrene, benzene, toluene, ethylbenzene, and xylenes (SBTEX). Presently, adverse health effects of ambient SBTEX exposure in highly polluted regions, such as the Gulf States, must be evaluated. Epidemiologists, however, are limited by inadequate estimates of ambient SBTEX.
View Article and Find Full Text PDFFactors associated with the dental service utilization by enrollees on the Lagos State health insurance scheme, Nigeria.
BMC Health Serv Res
January 2025
Oral Health Initiative, Nigerian Institute of Medical Research, Yaba, Lagos, Nigeria.
Background: Despite assumptions that insurance coverage would boost oral healthcare utilization in Nigeria, there is insufficient evidence supporting this claim. This study investigates the associations between residential location, awareness of the oral health insurance scheme, history of dental service utilization, and acceptance of oral health insurance among individuals benefiting from the Ilera Eko Scheme; a scheme that integrates preventive and curative oral health care into the state health insurance scheme.
Methods: A cross-sectional survey was conducted from July to November 2023 recruiting from a database of 1520 enrollees aged of 18 and 72-years-old who had been on the scheme for at least three months.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!